	US 12,357,583 B2
	Magnetoelectric nanocomposites and method of preparation thereof
Tahani Mohammed Alfareed, Dammam (SA); Munirah Abdullah Almessiere, Dammam (SA); Yassine Slimani, Dammam (SA); Firdos Alam Khan, Dammam (SA); Ebtesam Abdullah Al-Suhaimi, Dammam (SA); and Abdulhadi Baykal, Dammam (SA)
Assigned to Imam Abdulrahman Bin Faisal University, Dammam (SA)
Filed by Imam Abdulrahman Bin Faisal University, Dammam (SA)
Filed on Mar. 22, 2022, as Appl. No. 17/701,110.
Prior Publication US 2023/0320997 A1, Oct. 12, 2023
Int. Cl. A61K 9/51 (2006.01); A61K 45/06 (2006.01); B82Y 5/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01)

CPC A61K 9/5192 (2013.01) [A61K 45/06 (2013.01); B82Y 5/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01)]

7 Claims

1. A method of preferentially killing cancer cells, the method comprising:

contacting a magnetoelectric nanocomposite (MEN) and a cell culture comprising kidney (HEK)-293 cells or HCT-116 colorectal cancer cells, the MEN comprising:

a shell comprising barium titanate; and

a rare earth metal doped spinel ferrite nanoparticle (SFNP) core, having a formula of

Co_0.8Mn_0.2Eu_0.02Fe_1.98O₄,

wherein particles of the MEN have an average crystallite size of 41.25±0.05,

wherein upon the contacting with the MEN a higher percentage of the HCT-116 colorectal cancer cells are killed compared to the human embryonic kidney (HEK)-293, and

wherein, in the contacting, the cell culture of the HEK-293 cells or the HCT-116 colorectal cancer cells are contacted with the MEN in a range of from greater than 330 to less than 1410 g/mL for 48 hours.