	US 12,357,573 B2
	Pharmaceutical composition for drug delivery
Jonas Sävmarker, Uppsala (SE); Robert Rönn, Uppsala (SE); and Andreas Fischer, Uppsala (SE)
Assigned to OREXO AB, Uppsala (SE)
Filed by OREXO AB, Uppsala (SE)
Filed on Jun. 30, 2023, as Appl. No. 18/345,770.
Application 18/345,770 is a continuation of application No. 17/540,929, filed on Dec. 2, 2021, granted, now 11,737,980.
Application 17/540,929 is a continuation of application No. PCT/GB2021/051191, filed on May 18, 2021.
Claims priority of application No. 2007306 (GB), filed on May 18, 2020; application No. 2009905 (GB), filed on Jun. 29, 2020; and application No. 2018901 (GB), filed on Dec. 1, 2020.
Prior Publication US 2024/0024244 A1, Jan. 25, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/16 (2006.01); A61K 9/00 (2006.01); A61K 31/137 (2006.01)

CPC A61K 9/1652 (2013.01) [A61K 9/1623 (2013.01); A61K 9/1682 (2013.01); A61K 31/137 (2013.01); A61K 9/0078 (2013.01)]

54 Claims

1. A nasal applicator device for intranasal delivery of a composition to nasal mucosa, wherein the device comprises a reservoir that is within, or adjunct or attached to, said device, which reservoir contains a composition in the form of an amorphous powder, which amorphous powder comprises particles, is free of liquid propellant, and is essentially free of water,

wherein said amorphous powder comprises:

(a) a pharmacologically-effective dosage amount of epinephrine or a pharmaceutically-acceptable salt thereof as sole active ingredient; and

(b) a pharmaceutically-acceptable carrier material, which carrier material comprises a combination of a disaccharide and a polymeric material comprising a dextrin and/or hydroxypropylmethyl cellulose;

wherein the particles of the amorphous powder comprise an amorphous composite of epinephrine or salt thereof and the carrier material; and

wherein the nasal applicator device is configured and the particles are of a size whereby said device, upon actuation, is capable of depositing an effective dose of epinephrine, or salt thereof, to the nasal mucosa.