US 12,357,570 B2
Chemoembolization agents
James Na, San Diego, CA (US); David Imagawa, Oakland, CA (US); Fabio Tucci, San Diego, CA (US); Graham Beaton, San Diego, CA (US); and Satheesh Ravula, San Diego, CA (US)
Assigned to BRUIN BIOSCIENCES, INC., San Diego, CA (US); and THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed by BRUIN BIOSCIENCES, INC., San Diego, CA (US); and THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed on Jun. 19, 2023, as Appl. No. 18/211,428.
Application 18/211,428 is a division of application No. 16/616,808, granted, now 11,712,418, previously published as PCT/US2018/034744, filed on May 25, 2018.
Claims priority of provisional application 62/511,898, filed on May 26, 2017.
Claims priority of provisional application 62/511,895, filed on May 26, 2017.
Prior Publication US 2023/0346701 A1, Nov. 2, 2023
Int. Cl. A61K 9/127 (2025.01); A61K 9/1277 (2025.01); A61K 9/14 (2006.01); A61K 9/50 (2006.01); A61K 31/404 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61K 31/53 (2006.01); A61K 47/24 (2006.01); A61P 35/00 (2006.01)
CPC A61K 9/127 (2013.01) [A61K 9/1277 (2013.01); A61K 9/146 (2013.01); A61K 9/5026 (2013.01); A61K 31/404 (2013.01); A61K 31/44 (2013.01); A61K 31/47 (2013.01); A61K 31/53 (2013.01); A61K 47/24 (2013.01); A61P 35/00 (2018.01)] 18 Claims
OG exemplary drawing
 
1. A method of treating a cancer in a subject, the method comprising administering to a subject in need thereof a pharmaceutical composition of a pharmaceutically effective amount of a chemoembolization agent, comprising:
an embolizing particle or microsphere;
an encapsulating agent, the encapsulating agent being affixed to the embolizing particle or microsphere through ionic or other non-covalent interactions,
one or more therapeutic agents contained within the encapsulating agent,
wherein each therapeutic agent is independently uncharged or weakly charged or has low solubility in aqueous media at physiological pH; and
wherein the encapsulating agent is configured to release the one or more therapeutic agents.