	US 12,357,563 B2
	Long acting drug delivery device and its use in contraception
Svante Holmberg, Turku (FI); and Christine Talling, Turku (FI)
Assigned to Bayer Oy, Turku (FI)
Filed by Bayer OY, Turku (FI)
Filed on Jun. 30, 2021, as Appl. No. 17/364,199.
Application 17/364,199 is a continuation of application No. 15/573,187, granted, now 11,096,888, previously published as PCT/EP2016/060298, filed on May 9, 2016.
Claims priority of application No. 15167521 (EP), filed on May 13, 2015.
Prior Publication US 2021/0338573 A1, Nov. 4, 2021
Int. Cl. A61K 9/00 (2006.01); A61K 31/565 (2006.01); A61K 31/567 (2006.01)

CPC A61K 9/0036 (2013.01) [A61K 9/0039 (2013.01); A61K 31/565 (2013.01); A61K 31/567 (2013.01); A61K 9/0024 (2013.01)]

7 Claims

1. A method for altering the release characteristics of a long-acting drug delivery device containing two pharmaceutically active drugs, wherein the device has reduced initial release, the method comprising:

(i) making individual core segments of a polymer matrix material, wherein the individual core segments contain either active drug (A), active drug (B), or neither drug (inactive); and

(ii) assembling the individual core segments in the order A/B/A/inactive,

wherein the drug B is more soluble in the selected polymer matrix than drug A,

wherein the core segments are made of silicone elastomer material,

wherein the core segments are covered with a silicone based membrane, and

wherein the long-acting drug delivery device is an implant or an IUD.