US 12,357,544 B2
Curable composition for dentistry
Hiroshi Morisaki, Tokyo (JP); Tatsuya Yamazaki, Tokyo (JP); Takuma Matsuo, Tokyo (JP); and Hironobu Akizumi, Tokyo (JP)
Assigned to TOKUYAMA DENTAL CORPORATION, Tokyo (JP)
Appl. No. 17/788,253
Filed by TOKUYAMA DENTAL CORPORATION, Tokyo (JP)
PCT Filed Nov. 26, 2020, PCT No. PCT/JP2020/043971
§ 371(c)(1), (2) Date Jun. 22, 2022,
PCT Pub. No. WO2021/131476, PCT Pub. Date Jul. 1, 2021.
Claims priority of application No. 2019-232334 (JP), filed on Dec. 24, 2019.
Prior Publication US 2023/0039514 A1, Feb. 9, 2023
Int. Cl. A61K 6/887 (2020.01); A61K 6/62 (2020.01); A61K 6/76 (2020.01); A61K 6/853 (2020.01); A61K 6/878 (2020.01)
CPC A61K 6/887 (2020.01) [A61K 6/62 (2020.01); A61K 6/76 (2020.01); A61K 6/853 (2020.01); A61K 6/878 (2020.01)] 5 Claims
 
1. A curable composition for dentistry, comprising
a polymerizable monomer (A);
an inorganic filler (B) having an average particle size of 0.1 to 1 μm;
an organic-inorganic composite filler (C), and
a polymerization initiator (D),
the organic-inorganic composite filler (C) comprising organic-inorganic composite aggregate particles having an aggregated structure where inorganic primary particles having an average particle size of 10 to 1,000 nm are bonded together through a resin layer covering at least part of the surface of the inorganic primary particles so as to form a void;
the organic-inorganic composite filler (C) having pores where a total pore volume of pores having a pore size measured by a nitrogen adsorption method in the range of 1 to 500 nm is 0.01 to 0.30 cm3/g;
the organic-inorganic composite filler (C) having an average particle size of 10 to 100 μm;
wherein the organic-inorganic composite filler (C) comprises a curved surface-shaped organic-inorganic composite filler (C1) composed of organic-inorganic composite aggregate particles having a curved surface shape, and an irregular-shaped organic-inorganic composite filler (C2) composed of organic-inorganic composite aggregate particles having an irregular shape which comprises an edge portion, and
wherein a content ratio {C1/(C1+C2)} of the curved surface-shaped organic-inorganic composite filler (C1) accounting for the entire organic-inorganic composite filler (C) is 0.2 to 0.8, the content ratio being expressed in terms of a ratio of the total number of the curved surface-shaped organic-inorganic composite aggregate particles which have a particle size of 5 μm or more and which constitute the curved surface-shaped organic-inorganic composite filler (C1), accounting for the total number of the organic-inorganic composite aggregate particles having a particle size of 5 μm or more.