US 8,956,819 C1 (12,965th)
Identification of human mouse double minute 2 homolog nucleotide sequences
James Ryan, Augusta, GA (US)
Filed by Ryogen LLC, Suffern, NY (US)
Reexamination Request No. 90/019,533, Jun. 10, 2024.
Reexamination Certificate for Patent 8,956,819, issued Feb. 17, 2015, Appl. No. 13/680,247, Nov. 19, 2012.
Application 90/019,533 is a division of application No. 13/116,140, filed on May 26, 2011, granted, now 8,313,910.
Ex Parte Reexamination Certificate issued on Jul. 8, 2025.
Int. Cl. A61K 31/7088 (2006.01); C12N 9/48 (2006.01); C12Q 1/6876 (2018.01); C12Q 1/6883 (2018.01)
CPC A61K 31/7088 (2013.01) [C12N 9/48 (2013.01); C12Q 1/6876 (2013.01); C12Q 1/6883 (2013.01); C12Y 304/16005 (2013.01)]
AS A RESULT OF REEXAMINATION, IT HAS BEEN DETERMINED THAT:
Claims 1-3 are cancelled.
1. A method of identifying a nucleotide sequence variant of a 5′-noncoding region, 3′-noncoding region or intron region of SEQ ID NO:4 or its complementary sequence comprising
(a) isolating genomic polynucleotide from a subject and
(b) determining the presence or absence of a nucleotide sequence variation in said genomic polynucleotide by comparing the nucleotide sequence a 5′-noncoding region, 3′-noncoding region or intron region of SEQ ID NO:4 with the nucleotide sequence of the isolated genomic polynucleotide and establishing if and where a difference occurs between the two nucleic acid sequences thereby identifying a nucleotide sequence variant of a 5′-noncoding region, 3′-noncoding region or intron region of SEQ ID NO:4 or its complement.