US 12,031,962 B2
Method for identifying a reagent during a process in an analysis system
Dieter Heindl, Munich (DE); Thomas Heinemeyer, Penzberg (DE); Uwe Kobold, Weilheim (DE); Martin Rempt, Penzberg (DE); and Christoph Seidel, Weilheim (DE)
Assigned to Roche Diagnostics Operations, Inc., Indianapolis, IN (US)
Filed by Roche Diagnostics Operations, Inc., Indianapolis, IN (US)
Filed on Jun. 12, 2019, as Appl. No. 16/438,797.
Application 16/438,797 is a continuation of application No. PCT/EP2017/084027, filed on Dec. 21, 2017.
Claims priority of application No. 16206595 (EP), filed on Dec. 23, 2016.
Prior Publication US 2019/0293612 A1, Sep. 26, 2019
Int. Cl. G01N 30/46 (2006.01); G01N 30/02 (2006.01); G01N 30/06 (2006.01); G01N 30/28 (2006.01); G01N 30/72 (2006.01); G01N 33/58 (2006.01)
CPC G01N 30/466 (2013.01) [G01N 30/06 (2013.01); G01N 30/28 (2013.01); G01N 30/7233 (2013.01); G01N 33/58 (2013.01); G01N 2030/027 (2013.01); G01N 2030/067 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method for identifying a reagent lot during a process in an analysis system, wherein the analysis system comprises a liquid chromatograph and a mass spectrometer, the method comprising:
1) adding at least one chemical substance with a concentration detectable by the mass spectrometer to a reagent in a specific reagent lot, thereby coding the specific reagent lot, wherein the reagent is a solvent, the chemical substance is spiked into the reagent during production of the specific reagent lot and wherein the at least one chemical substance is selected from the group consisting of peptides, derivatives of peptides, peptide nucleic acids, oligonucleotides, carbohydrates, derivatives of carbohydrates, oligomers, and combinations thereof,
2) once added, processing the reagent and the added chemical substance together, using the analysis system, and
3) identifying the specific reagent lot based on a detection of a substance detection signal of the at least one chemical substance using the mass spectrometer,
and wherein the identity of the specific reagent lot is traced back during sample analysis during step 2).