US 12,031,235 B2
Nanofiber composite membrane for guided bone regeneration, and manufacturing method therefor
Chan Kim, Gwangju (KR); Seung Hoon Lee, Paju-si (KR); Seon Ho Jang, Seoul (KR); Ji Hyun Lee, Incheon (KR); and Yun Mi So, Incheon (KR)
Assigned to AMOGREENTECH CO., LTD., Gimpo-si (KR)
Filed by AMOGREENTECH CO., LTD., Gimpo-si (KR)
Filed on Jan. 18, 2021, as Appl. No. 17/151,308.
Application 17/151,308 is a continuation in part of application No. 16/093,368, abandoned, previously published as PCT/KR2017/004044, filed on Apr. 14, 2017.
Claims priority of application No. 10-2016-0052342 (KR), filed on Apr. 28, 2016.
Prior Publication US 2021/0140070 A1, May 13, 2021
Int. Cl. A61L 27/54 (2006.01); A61F 2/07 (2013.01); A61L 24/00 (2006.01); A61L 27/12 (2006.01); A61L 27/26 (2006.01); A61L 31/16 (2006.01); D01D 5/00 (2006.01); D01F 1/10 (2006.01); B82Y 5/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01)
CPC D01D 5/003 (2013.01) [A61L 24/0042 (2013.01); A61L 27/12 (2013.01); A61L 27/26 (2013.01); A61L 2300/112 (2013.01); A61L 2300/20 (2013.01); A61L 2300/412 (2013.01); A61L 2430/02 (2013.01); A61L 2430/38 (2013.01); B82Y 5/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method of manufacturing a nanofiber composite membrane for guided bone regeneration, the method comprising:
preparing a first spinning solution by mixing an electro-spinnable non-absorbent polymer material, a biocompatible plasticizer, and a solvent at a predetermined ratio;
electro-spinning the first spinning solution to form a non-absorbent membrane made of first accumulated electro-spun nanofibers;
prepare a second spinning solution by mixing an electro-spinnable non-absorbent polymer material, a biocompatible plasticizer, a guided bone regeneration material and a solvent at a predetermined ratio;
electro-spinning the second spinning solution to form an absorbent membrane made of second accumulated electro-spun nanofibers;
laminating the non-absorbent membrane and the absorbent membrane to form a composite membrane; and
thermal calendaring the composite membrane having a certain thickness.