US 12,030,986 B2
Sustained release composition using biobased biodegradable hyperbranched polyesters
Patrick B. Smith, Midland, MI (US); Bobby A. Howell, Mt. Pleasant, MI (US); and Cuiwei Zhang, Midland, MI (US)
Assigned to CENTRAL MICHIGAN UNIVERSITY, Mt. Pleasant, MI (US)
Filed by CENTRAL MICHIGAN UNIVERSITY, Mt. Pleasant, MI (US)
Filed on May 6, 2020, as Appl. No. 16/868,339.
Application 16/868,339 is a continuation of application No. 15/121,746, abandoned, previously published as PCT/US2015/017069, filed on Feb. 23, 2015.
Claims priority of provisional application 61/946,599, filed on Feb. 28, 2014.
Prior Publication US 2020/0262974 A1, Aug. 20, 2020
Int. Cl. A01N 25/10 (2006.01); A01N 25/18 (2006.01); A01N 31/14 (2006.01); A01N 35/02 (2006.01); A01N 37/10 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61K 31/165 (2006.01); A61K 31/192 (2006.01); A61K 31/198 (2006.01); A61K 31/573 (2006.01); A61K 31/60 (2006.01); A61K 47/34 (2017.01); C08G 63/12 (2006.01); C08G 63/91 (2006.01); C08L 101/00 (2006.01); C08L 101/16 (2006.01)
CPC C08G 63/914 (2013.01) [A01N 25/10 (2013.01); A01N 25/18 (2013.01); A01N 31/14 (2013.01); A01N 35/02 (2013.01); A01N 37/10 (2013.01); A61K 9/0014 (2013.01); A61K 9/7007 (2013.01); A61K 31/165 (2013.01); A61K 31/192 (2013.01); A61K 31/198 (2013.01); A61K 31/573 (2013.01); A61K 31/60 (2013.01); A61K 47/34 (2013.01); C08G 63/12 (2013.01); C08L 101/005 (2013.01); C08L 101/16 (2013.01); C08G 2220/00 (2013.01); C08G 2310/00 (2013.01)] 21 Claims
 
1. A composition comprising:
a) a synthetic or natural biobased, biodegradable hyperbranched polyester (HB-PE), wherein the HB-PE is derived from a reaction between glycerol and a difunctional acid having two acid groups, wherein the molar ratio of alcohol groups to acid groups is greater than or equal to 2 or less than or equal to 0.5, wherein the extent of reaction of the minor component among the glycerol and difunctional acid is about unity; and
b) an active ingredient covalently bonded to end groups of the HB-PE;
wherein the composition is a viscous liquid.