US 12,030,985 B2
Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof
W. Mark Saltzman, New Haven, CT (US); and Yuhang Jiang, New Haven, CT (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US)
Filed by Yale University, New Haven, CT (US)
Filed on Jul. 28, 2023, as Appl. No. 18/361,630.
Application 18/361,630 is a division of application No. 16/862,491, filed on Apr. 29, 2020, granted, now 11,814,464.
Claims priority of provisional application 62/840,220, filed on Apr. 29, 2019.
Prior Publication US 2024/0092968 A1, Mar. 21, 2024
Int. Cl. C08G 63/685 (2006.01); A61K 47/59 (2017.01)
CPC C08G 63/685 (2013.01) [A61K 47/595 (2017.08)] 20 Claims
 
1. A method of administering one or more therapeutic, diagnostic, or prophylactic nucleic acid agents, or combinations thereof in vivo, comprising administering to a subject or a cell in need thereof a polyplex or solid-core particle comprising the one or more therapeutic, prophylactic, or diagnostic nucleic acid agents and a polymer of Formula I:

OG Complex Work Unit Chemistry
wherein n is an integer from 1-30, m, o, and p are independently integers from 1-20, x, y, and q are independently integers from 1-1000, Rx is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted alkoxy, Z and Z′ are independently O or NR′, wherein R′ is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl,
wherein R1 and R2 are chemical entities containing a hydroxyl group, a primary amine group, a secondary amine group, a tertiary amine group, or combinations thereof.