CPC C07K 14/755 (2013.01) [A61P 7/04 (2018.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01)] | 19 Claims |
1. A method of treating hemophilia A comprising administering multiple doses of a chimeric polypeptide at a dosing interval to a human subject in need thereof, wherein the chimeric polypeptide comprises:
(i) a FVIII protein comprising the amino acid sequence of SEQ ID NO: 207; and
(ii) a VWF protein comprising the amino acid sequence of SEQ ID NO: 202;
wherein each of the multiple doses is from 45 IU/kg to 55 IU/kg and the dosing interval is at least 6 days to 8 days; and
wherein the multiple doses are administered for at least about 6 months;
wherein the chimeric polypeptide is administered for prophylactic treatment;
wherein the subject has less than 1 IU/dL endogenous FVIII;
wherein the subject is at least 12 years of age;
wherein the FVIII protein is covalently linked to the VWF protein by a disulfide bond, and
wherein the chimeric polypeptide is administered intravenously.
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