US 12,030,863 B2
Prodrugs of urolithins and uses thereof
Christopher L. Rinsch, Lausanne (CH); and Rune Andreas Ringom, Uppsala (CH)
Assigned to Amazentis SA, Lausanne (CH)
Filed by Amazentis SA, Lausanne (CH)
Filed on Nov. 2, 2021, as Appl. No. 17/516,865.
Application 17/516,865 is a continuation of application No. 16/741,221, filed on Jan. 13, 2020, granted, now 11,180,468.
Application 16/741,221 is a continuation of application No. 16/005,160, filed on Jun. 11, 2018, granted, now 10,532,992.
Application 16/005,160 is a continuation of application No. 15/107,467, granted, now 9,994,542, previously published as PCT/EP2014/079189, filed on Dec. 23, 2014.
Claims priority of application No. 1323008 (GB), filed on Dec. 24, 2013.
Prior Publication US 2022/0127240 A1, Apr. 28, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 311/80 (2006.01); A61K 31/352 (2006.01); A61K 31/366 (2006.01); A61K 31/4025 (2006.01); A61K 45/06 (2006.01); A61P 3/00 (2006.01); C07D 405/12 (2006.01)
CPC C07D 311/80 (2013.01) [A61K 31/366 (2013.01); A61K 31/4025 (2013.01); A61K 45/06 (2013.01); C07D 405/12 (2013.01)] 10 Claims
 
1. A compound of formula (I) or a salt thereof:

OG Complex Work Unit Chemistry
wherein:
A, B, C, W, X and Y are H,
D and Z are independently OR1;
each R1 is independently C(═O)R2;
each R2 is independently selected from:
CHR3NHR4, where R4 is H and R3 is a group selected from CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, CH2Ph, CH2-3-(1H-indole), CH2CH2SCH3, CH2OH, CHOHCH3, CH2SH, CH2SeH and CH2PhpOH,
wherein said R3 group can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C4 alkyl;
or R3 and R4 together with the C and N atoms to which they are attached form a 5-membered heteroalkyl ring,
wherein said heteroalkyl ring can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C3 alkyl,
wherein RA is C1-C4 alkyl optionally substituted with one or more halogen, cyano or nitro groups.