US 12,030,856 B2
Potassium channel inhibitors
Antonio Mete, Loughborough (GB); and Ulrik Sørensen, Copenhagen N (DK)
Assigned to ACESION PHARMA APS, Copenhagen N (DK)
Filed by ACESION PHARMA APS, Copenhagen N (DK)
Filed on Aug. 28, 2023, as Appl. No. 18/238,732.
Application 18/238,732 is a continuation of application No. PCT/EP2023/056277, filed on Mar. 13, 2023.
Claims priority of application No. 22162647 (EP), filed on Mar. 17, 2022.
Prior Publication US 2023/0399301 A1, Dec. 14, 2023
Int. Cl. C07D 233/88 (2006.01)
CPC C07D 233/88 (2013.01) 14 Claims
 
1. A compound of formula (I)

OG Complex Work Unit Chemistry
Wherein
R1 is selected from hydrogen and C1-6 alkyl;
R2-R3 are independently a group selected from hydrogen and C1-6 alkyl;
or R2 and R3 taken together with the carbon atom to which they are linked form a C3-4 cycloalkyl;
R4-R6 are independently a group selected from hydrogen, halogen, and C1-4 alkyl;
R7 is selected from the group consisting of hydrogen and C1-4 alkyl,
R8 is selected from the group consisting of C1-6 alkyl, C1-6 alkyl substituted with one OH, and C1-6 alkyl substituted with one OC1-3 alkyl,
or R7 and R8 taken together with the carbon atom to which they are linked form a C3-4 cycloalkyl;
R9-R13 are independently a group selected from hydrogen, halogen, C1-6 alkyl substituted with at least one halogen, C1-6 alkoxy, C1-6 alkoxy substituted with at least one halogen, C1-6 alkylthio, and cyano;
R14 is selected from H, C1-6 alkyl, or C1-6 alkoxy;
R15 is selected from H, C1-6 alkyl, C1-6 alkyl substituted with at least one halogen, C1-6 alkoxy, C1-6 alkoxy substituted with at least one a halogen, or C3-4 cycloalkyl;
or R14 and R15 taken together with the nitrogen atom to which they are linked form a 4-6 membered non-aromatic heterocycle containing 1-2 nitrogen atoms, optionally 1 oxygen atom, and optionally 1 sulphur atom, optionally substituted with at least one group selected from halogen, C1-6 alkyl, C1-6 alkyl substituted with at least one halogen, C1-6 alkoxy, C1-6 alkoxy substituted with at least one halogen; or
a pharmaceutically acceptable salt thereof.