US 12,030,834 B2
Methods of synthesizing 4-valyloxybutyric acid
Jia-Ning Xiang, Fremont, CA (US); Hao-Wei Shih, New Taipei (TW); Xiaoming Wu, Wuhan (CN); Xuan Zhang, Wuhan (CN); and James Tien, Taoyuan (TW)
Assigned to XWPHARMA LTD., Grand Cayman (KY)
Filed by XWPHARMA LTD., Grand Cayman (KY)
Filed on Jul. 12, 2023, as Appl. No. 18/221,075.
Application 18/221,075 is a continuation of application No. 17/673,335, filed on Feb. 16, 2022, granted, now 11,746,081.
Application 17/673,335 is a continuation of application No. 17/351,550, filed on Jun. 18, 2021, granted, now 11,279,669, issued on Mar. 22, 2022.
Application 17/351,550 is a continuation of application No. PCT/US2020/066047, filed on Dec. 18, 2020.
Claims priority of application No. PCT/CN2019/127065 (WO), filed on Dec. 20, 2019.
Prior Publication US 2023/0357130 A1, Nov. 9, 2023
Int. Cl. C07C 229/08 (2006.01); C07C 227/16 (2006.01); C07C 227/18 (2006.01); C07C 227/20 (2006.01); C07C 269/06 (2006.01); C07C 271/22 (2006.01)
CPC C07C 229/08 (2013.01) [C07C 227/16 (2013.01); C07C 227/18 (2013.01); C07C 227/20 (2013.01); C07C 269/06 (2013.01); C07C 271/22 (2013.01)] 7 Claims
 
1. A method of preparing a compound of Formula (I-D):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, comprising contacting a compound of Formula (I-E):

OG Complex Work Unit Chemistry
with gaseous hydrogen in the presence of a catalyst and a solvent.