US 12,029,914 B2
Phototherapeutic light for treatment of pathogens
Nathan Stasko, Chapel Hill, NC (US); David T. Emerson, Durham, NC (US); Adam Cockrell, Durham, NC (US); F. Neal Hunter, Durham, NC (US); Michael John Bergmann, Atlanta, GA (US); Rebecca McDonald, Chapel Hill, NC (US); Nicholas William Medendorp, Jr., Raleigh, NC (US); Gerald H. Negley, Chapel Hill, NC (US); and Katelyn P. Reighard, Durham, NC (US)
Assigned to KNOW Bio, LLC, Morrisville, NC (US)
Filed by KNOW Bio, LLC, Durham, NC (US)
Filed on Jan. 13, 2021, as Appl. No. 17/148,133.
Application 17/148,133 is a division of application No. 17/117,858, filed on Dec. 10, 2020.
Application 17/117,858 is a continuation in part of application No. 16/898,385, filed on Jun. 10, 2020, granted, now 11,617,895.
Application 16/898,385 is a continuation of application No. 16/709,550, filed on Dec. 10, 2019, granted, now 11,524,173.
Application 16/709,550 is a continuation of application No. 15/222,199, filed on Jul. 28, 2016, granted, now 10,525,275.
Claims priority of provisional application 63/123,631, filed on Dec. 10, 2020.
Claims priority of provisional application 63/084,802, filed on Sep. 29, 2020.
Claims priority of provisional application 63/074,800, filed on Sep. 4, 2020.
Claims priority of provisional application 62/987,318, filed on Mar. 9, 2020.
Claims priority of provisional application 62/197,746, filed on Jul. 28, 2015.
Prior Publication US 2021/0128938 A1, May 6, 2021
Int. Cl. A61N 5/06 (2006.01); H01L 27/15 (2006.01)
CPC A61N 5/0613 (2013.01) [A61N 5/0601 (2013.01); A61N 5/0603 (2013.01); A61N 5/0624 (2013.01); H01L 27/15 (2013.01); A61N 2005/0611 (2013.01); A61N 2005/0626 (2013.01); A61N 2005/0647 (2013.01); A61N 2005/0652 (2013.01); A61N 2005/0653 (2013.01); A61N 2005/0661 (2013.01); A61N 2005/0662 (2013.01); A61N 2005/0663 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method comprising:
providing light comprising a first peak wavelength in a range from 400 nanometers (nm) to 900 nm; and
administering a dose of the light to mammalian tissue within a body to induce a biological effect, the dose of light comprising providing an average irradiance to the tissue over a time period of at most 1 hour, the average irradiance being no more than 1 watt per square centimeter (W/cm2) delivered in a plurality of discrete pulses, each discrete pulse of the plurality of discrete pulses having an irradiance to the tissue in a range from greater than 1 W/cm2 to 10 W/cm2;
wherein the biological effect comprises altering a concentration of one or more pathogens within the body and altering growth of the one or more pathogens within the body.