US 12,029,907 B2
Method and apparatus for improving cognitive performance through cortical stimulation
Michael Kahana, Merion Station, PA (US); and Daniel Sutton Rizzuto, Philadelphia, PA (US)
Assigned to THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
Appl. No. 16/318,738
Filed by The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
PCT Filed Jul. 19, 2017, PCT No. PCT/US2017/042759
§ 371(c)(1), (2) Date Jan. 18, 2019,
PCT Pub. No. WO2018/017655, PCT Pub. Date Jan. 25, 2018.
Claims priority of provisional application 62/365,538, filed on Jul. 22, 2016.
Prior Publication US 2019/0282815 A1, Sep. 19, 2019
Int. Cl. A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61B 5/24 (2021.01); A61B 5/291 (2021.01); A61B 5/369 (2021.01); A61N 1/05 (2006.01)
CPC A61N 1/36092 (2013.01) [A61B 5/24 (2021.01); A61B 5/291 (2021.01); A61B 5/369 (2021.01); A61N 1/0531 (2013.01); A61N 1/36082 (2013.01); A61N 1/36139 (2013.01); A61N 1/36171 (2013.01); A61N 1/36175 (2013.01); A61B 5/4064 (2013.01); A61B 5/4088 (2013.01); A61B 5/4836 (2013.01); A61B 5/686 (2013.01); A61N 1/36157 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A method for treating a human cognitive disorder or enhancing normal cognition using a neurostimulator device including a signal generator and a lead having a proximal end coupled to the signal generator and a distal portion having at least one electrode, the method comprising:
(a) implanting a sensor only within a left middle temporal gyrus of a brain;
(b) implanting a stimulation portion of the at least one electrode within only the left middle temporal gyrus of a brain;
(c) coupling the at least one electrode to the signal generator using the lead;
(d) sensing an electrophysiological characteristic indicative of normal, enhanced, or impaired cognition only at the left middle temporal gyrus with the sensor;
(e) determining an appropriate level of electrical stimulation based on the sensed electrophysiological characteristic; and
(f) treating the cognitive disorder or enhancing normal cognition by operating the signal generator to deliver stimulation at the appropriate level only to the left middle temporal gyrus of the brain via the electrode.