	US 12,029,831 B2
	Silver nanoplate compositions and methods
Steven J. Oldenburg, San Diego, CA (US); Martin Miranda, San Diego, CA (US); David S. Sebba, Cary, NC (US); and Todd J. Harris, Carlsbad, CA (US)
Assigned to CORONADO AESTHETICS, LLC, Southlake, TX (US); and NANOCOMPOSIX, INC., San Diego, CA (US)
Filed by CORONADO AESTHETICS, LLC, Southlake, TX (US); and nanoComposix, Inc., San Diego, CA (US)
Filed on Dec. 27, 2022, as Appl. No. 18/089,047.
Application 18/089,047 is a continuation of application No. 16/902,455, filed on Jun. 16, 2020, granted, now 11,583,553.
Application 16/902,455 is a continuation of application No. 15/374,942, filed on Dec. 9, 2016, granted, now 10,688,126, issued on Jun. 23, 2020.
Application 15/374,942 is a continuation of application No. 14/947,508, filed on Nov. 20, 2015, granted, now 9,526,745, issued on Dec. 27, 2016.
Application 14/947,508 is a continuation of application No. 14/681,379, filed on Apr. 8, 2015, granted, now 9,212,294, issued on Dec. 15, 2015.
Application 14/681,379 is a continuation of application No. PCT/US2013/063920, filed on Oct. 8, 2013.
Prior Publication US 2023/0139868 A1, May 4, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C09D 129/04 (2006.01); A61K 9/51 (2006.01); A61K 33/38 (2006.01); A61K 47/24 (2006.01); A61K 47/32 (2006.01); A61L 27/00 (2006.01); B22F 1/054 (2022.01); B22F 1/0545 (2022.01); B22F 1/14 (2022.01); B22F 1/145 (2022.01); B22F 1/16 (2022.01); C08J 3/205 (2006.01); C08K 3/08 (2006.01); C08K 3/28 (2006.01); C08K 3/36 (2006.01); C08K 3/38 (2006.01); C08K 5/092 (2006.01); C08K 5/1535 (2006.01); C09D 125/06 (2006.01); C09D 139/06 (2006.01); B22F 1/068 (2022.01)

CPC A61L 27/00 (2013.01) [A61K 9/5115 (2013.01); A61K 9/5123 (2013.01); A61K 9/5138 (2013.01); A61K 33/38 (2013.01); A61K 47/24 (2013.01); A61K 47/32 (2013.01); B22F 1/0545 (2022.01); B22F 1/0551 (2022.01); B22F 1/14 (2022.01); B22F 1/145 (2022.01); B22F 1/147 (2022.01); B22F 1/16 (2022.01); C08J 3/2053 (2013.01); C08K 3/08 (2013.01); C08K 3/28 (2013.01); C08K 3/36 (2013.01); C08K 3/38 (2013.01); C08K 5/092 (2013.01); C08K 5/1535 (2013.01); C09D 125/06 (2013.01); C09D 129/04 (2013.01); C09D 139/06 (2013.01); A61L 2300/104 (2013.01); B22F 1/068 (2022.01); B22F 2301/255 (2013.01); B22F 2998/10 (2013.01); C08J 2325/18 (2013.01); C08J 2329/04 (2013.01); C08K 2003/0806 (2013.01)]

7 Claims

1. A process for generating a solution of silver nanoplates comprising the steps of:

forming a plurality of silver seeds from a solution, wherein the solution comprises a reducing agent, a stabilizing agent that is a salt, a polymer, or a biomolecule, and a silver salt;

growing the plurality of silver seeds into a plurality of silver nanoplates in the solution;

adding a buffer to the solution comprising the plurality of silver nanoplates, wherein the buffer is a sulfate, carbonate, chromate, borate, sulfite, acetate, or nitrate buffer; and

concentrating the solution of silver nanoplates until a peak optical density of the solution is greater than about 10 cm⁻¹;

isolating the concentrated silver nanoplates; and

encapsulating the isolated concentrated silver nanoplates with silica, wherein the silver nanoplates are functionalized with a functional group or groups selected from one or more of the following: thiol, acrylate, alkyne, maleimide, silane, azide, hydroxyl, lipid, disulfide, fluorescent molecule, biotin, or combinations thereof.