Compositions and methods of making brittle-matrix particles through blister pack freezing
Keith P. Johnston, Austin, TX (US); Joshua Engstrom, Spotswood, NJ (US); Jasmine Rowe, Austin, TX (US); Alan B. Watts, Plainsboro, NJ (US); and Robert O. Williams, III, Austin, TX (US)
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed by BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed on May 17, 2022, as Appl. No. 17/746,915.
Application 17/746,915 is a continuation of application No. 16/839,957, filed on Apr. 3, 2020, granted, now 11,364,197.
Application 16/839,957 is a continuation of application No. 16/555,165, filed on Aug. 29, 2019, granted, now 10,660,850, issued on May 26, 2020.
Application 16/555,165 is a continuation of application No. 16/115,888, filed on Aug. 29, 2018, granted, now 10,434,062, issued on Apr. 25, 2019.
Application 16/115,888 is a continuation of application No. 12/778,795, filed on May 12, 2010, granted, now 10,092,512, issued on Oct. 9, 2018.
Prior Publication US 2022/0354778 A1, Nov. 10, 2022
1. A porous matrix of nano-structured primary particles of the one or more active agents, wherein the primary particles have a particle size of about 50 to about 500 nanometers (nm), wherein upon pulmonary delivery the nano-structured matrix of primary particles are fractured to release primary particles or aggregates of said primary particles.