US 12,029,788 B2
Methods for increasing lean body mass with an exercise regimen and a GDF8 inhibitor that is an anti-GDF8 antibody
Robert C. Pordy, Ardsley, NY (US); Xiaobing Qian, Briarcliff Manor, NY (US); and Stephen Donahue, Princeton, NY (US)
Assigned to Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed by Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed on Jan. 14, 2021, as Appl. No. 17/149,540.
Application 17/149,540 is a continuation of application No. 15/099,701, filed on Apr. 15, 2016, granted, now 10,934,349.
Claims priority of provisional application 62/261,528, filed on Dec. 1, 2015.
Claims priority of provisional application 62/234,899, filed on Sep. 30, 2015.
Claims priority of provisional application 62/147,853, filed on Apr. 15, 2015.
Prior Publication US 2021/0246198 A1, Aug. 12, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/395 (2006.01); A61P 21/00 (2006.01); A61K 39/00 (2006.01); C07K 14/47 (2006.01); C07K 14/475 (2006.01); C07K 16/22 (2006.01)
CPC A61K 39/3955 (2013.01) [A61K 2039/505 (2013.01); C07K 14/4703 (2013.01); C07K 14/4716 (2013.01); C07K 14/475 (2013.01); C07K 16/22 (2013.01); C07K 2317/21 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/76 (2013.01)] 26 Claims
 
1. A method for increasing lean body mass in a subject experiencing or at risk of age-related loss of lean muscle mass and/or a disease, disorder, or condition associated with a decrease in skeletal muscle mass comprising:
a. providing an exercise regimen for the subject, wherein the exercise regimen comprises resistance training; and
b. administering a composition comprising an effective amount of a Growth and Differentiation Factor-8 (GDF-8) inhibitor, wherein the GDF-8 inhibitor is an antibody or antigen-binding fragment thereof that specifically binds GDF-8.