US 12,029,776 B2
Composition for treating cancer and use and medicament thereof
Zhongjie Sun, Beijing (CN); Hailong Qi, Beijing (CN); Ligong Chen, Beijing (CN); Huangfan Xie, Beijing (CN); Defang Liu, Beijing (CN); Xiao E. Yan, Beijing (CN); Weiwei Li, Beijing (CN); and Xiaofang Wang, Beijing (CN)
Assigned to NEWISH TECHNOLOGY (BEIJING) CO., LTD., Beijing (CN)
Appl. No. 17/292,835
Filed by NEWISH TECHNOLOGY (BEIJING) CO., LTD., Beijing (CN)
PCT Filed Aug. 19, 2020, PCT No. PCT/CN2020/109967
§ 371(c)(1), (2) Date May 11, 2021,
PCT Pub. No. WO2022/007135, PCT Pub. Date Jan. 13, 2022.
Claims priority of application No. 202010641456.1 (CN), filed on Jul. 6, 2020.
Prior Publication US 2022/0305072 A1, Sep. 29, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61P 35/00 (2006.01); A61K 31/351 (2006.01)
CPC A61K 38/005 (2013.01) [A61K 38/179 (2013.01); A61K 38/1866 (2013.01); A61P 35/00 (2018.01); A61K 31/351 (2013.01)] 5 Claims
 
1. A composition comprising a sodium/glucose co-transporter 1 inhibitor and a vascular endothelial growth factor receptor 2 inhibitor, wherein the sodium/glucose co-transporter 1 inhibitor is sotagliflozin; and wherein the vascular endothelial growth factor receptor 2 inhibitor is selected from at least one of apatinib, axitinib, nintedanib, cediranib, pazopanib hydrochloride, sunitinib malate, brivanib, cabozantinib, brivanib alaninate, lenvatinib, regorafenib, ENMD-2076, ENMD-2076 L-(+)-tartaric acid, tivozanib, ponatinib, fruquintinib, telatinib, taxifolin, pazopanib, cabozantinib malate, vitamin E, regorafenib monohydrate, nintedanib ethanesulfonate salt, lenvatinib mesylate, cediranibmaleate, 4-[(1E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridyl)ethoxyl-1H-indazol-3-yl]vinyl]-1H-pyrazole-1-ethanol, sunitinib, sitravatinib, anlotinib dihydrochloride, sorafenib, vandetanib and a monoclonal antibody medicament targeting vascular endothelial growth factor receptor; wherein the sodium/glucose co-transporter 1 inhibitor is at a dosage of 1 to 100 mg/kg and the vascular endothelial growth factor receptor 2 inhibitor is at a dosage of 10 to 500 mg/kg.