US 12,029,730 B2
Pharmaceutical composition for preventing or treating cancer, containing N-1H-benzimidazol-2-yl-3-(1H-pyrrole-1-yl)benzamide as active ingredient
Jae Sung Kim, Namyangju-si (KR); Ah Young Kim, Seoul (KR); Sang Gu Hwang, Seoul (KR); Jie Young Song, Seoul (KR); and Yi Na Yoon, Incheon (KR)
Assigned to KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES, Seoul (KR)
Appl. No. 17/285,464
Filed by KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES, Seoul (KR)
PCT Filed Sep. 3, 2019, PCT No. PCT/KR2019/011332
§ 371(c)(1), (2) Date Apr. 14, 2021,
PCT Pub. No. WO2020/085642, PCT Pub. Date Apr. 30, 2020.
Claims priority of application No. 10-2018-0126869 (KR), filed on Oct. 23, 2018.
Prior Publication US 2021/0379022 A1, Dec. 9, 2021
Int. Cl. A61K 31/4184 (2006.01); A23L 33/10 (2016.01); A61P 35/00 (2006.01)
CPC A61K 31/4184 (2013.01) [A23L 33/10 (2016.08); A61P 35/00 (2018.01); A23V 2002/00 (2013.01)] 7 Claims
 
1. A method of treating cancer in a subject in need thereof, comprising:
administering a pharmaceutical composition comprising N-1H-benzimidazol-2-yl-3-(1H-pyrrol-1-yl) benzamide represented by following Chemical Formula, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient to the subject,
wherein the cancer is at least one selected from the group consisting of brain tumor, benign astrocytoma, malignant astrocytoma, pituitary adenoma, meningioma, cerebral lymphoma, oligodendroglioma, intracranial tumor, ependymoma, brain stem tumor, head and neck tumor, laryngeal cancer, oropharyngeal cancer, nasal and paranasal cavity cancer, nasopharyngeal cancer, salivary gland cancer, hypopharyngeal cancer, thyroid cancer, thoracic tumor, small cell lung cancer, non-small cell lung cancer, thymus cancer, mediastinal tumor, esophageal cancer, breast cancer, male breast cancer, abdominal tumor, gastric cancer, liver cancer, gallbladder cancer, biliary tract cancer, pancreatic cancer, small intestine cancer, colon cancer, anal cancer, bladder cancer, kidney cancer, male genital tumor, penile cancer, urethral cancer, prostate cancer, female genital tumor, cervical cancer, endometrial cancer, ovarian cancer, uterine sarcoma, vaginal cancer, vulva cancer, female urethral cancer, skin cancer, myeloma, leukemia and malignant lymphoma:

OG Complex Work Unit Chemistry