US 12,029,728 B2
Small molecules with anti-protozoan activity
Snezna Rogelj, Socorro, NM (US); Danielle Nicole Turner, Socorro, NM (US); Ivy Hurwitz, Socorro, NM (US); and Alexander Aksenov, Socorro, NM (US)
Assigned to New Mexico Tech University Research Park Corporation, Socorro, NM (US)
Appl. No. 17/286,599
Filed by New Mexico Tech University Research Park Corporation, Socorro, NM (US)
PCT Filed Oct. 29, 2019, PCT No. PCT/US2019/058572
§ 371(c)(1), (2) Date Apr. 19, 2021,
PCT Pub. No. WO2020/092374, PCT Pub. Date May 7, 2020.
Claims priority of provisional application 62/752,548, filed on Oct. 30, 2018.
Prior Publication US 2021/0386707 A1, Dec. 16, 2021
Int. Cl. A61K 31/405 (2006.01); A61K 31/404 (2006.01); A61P 33/02 (2006.01)
CPC A61K 31/405 (2013.01) [A61K 31/404 (2013.01); A61P 33/02 (2018.01)] 11 Claims
 
1. A method of treating a protozoan infection, the method comprising: administering to a subject in need thereof a therapeutically-effective amount of a compound of the formula:

OG Complex Work Unit Chemistry
wherein:
R1 is —CN, —C(═O)NHOH, or —C(═O)NH2;
R2 is substituted or unsubstituted phenyl;
R3 is methyl, phenyl, naphthalen-1-yl, or naphthalen-2-yl;
R4 is methyl, ethyl, n-propyl, n-butyl, or hydrogen; and
each R5, R6, R7, and R8 is hydrogen,
or a pharmaceutically-acceptable salt thereof.