US 12,029,708 B2
Alkoxy compounds for disease treatment
Ian L. Scott, Trabuco Canyon, CA (US); Vladimir A. Kuksa, Bothell, WA (US); Mark W. Orme, Seattle, WA (US); Thomas L Little, Jr., Seattle, WA (US); Anna Gall, Woodinville, WA (US); and Feng Hong, Bellevue, WA (US)
Assigned to ACUCELA INC., Seattle, WA (US)
Filed by Acucela Inc., Seattle, WA (US)
Filed on Aug. 5, 2022, as Appl. No. 17/817,927.
Application 17/817,927 is a continuation of application No. 16/865,195, filed on May 1, 2020, granted, now 11,446,261.
Application 16/865,195 is a continuation of application No. 16/043,019, filed on Jul. 23, 2018, granted, now 10,639,286, issued on May 5, 2020.
Application 16/043,019 is a continuation of application No. 15/672,031, filed on Aug. 8, 2017, granted, now 10,188,615, issued on Jan. 29, 2019.
Application 15/672,031 is a continuation of application No. 15/260,127, filed on Sep. 8, 2016, granted, now 9,737,496, issued on Aug. 22, 2017.
Application 15/260,127 is a continuation of application No. 14/631,779, filed on Feb. 25, 2015, abandoned.
Application 15/260,127 is a continuation of application No. 14/631,763, filed on Feb. 25, 2015, granted, now 9,458,088, issued on Oct. 4, 2016.
Application 14/631,779 is a continuation of application No. 13/111,679, filed on May 19, 2011, granted, now 8,981,153, issued on Mar. 17, 2015.
Application 14/631,779 is a continuation of application No. 13/111,679, filed on May 19, 2011, granted, now 8,981,153, issued on Mar. 17, 2015.
Application 13/111,679 is a continuation of application No. 12/287,039, filed on Oct. 3, 2008, granted, now 7,982,071, issued on Jul. 19, 2011.
Claims priority of provisional application 61/060,083, filed on Jun. 9, 2008.
Claims priority of provisional application 61/051,657, filed on May 8, 2008.
Claims priority of provisional application 61/043,127, filed on Apr. 7, 2008.
Claims priority of provisional application 61/066,353, filed on Feb. 19, 2008.
Claims priority of provisional application 60/977,957, filed on Oct. 5, 2007.
Prior Publication US 2023/0218549 A1, Jul. 13, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/137 (2006.01); A61K 31/165 (2006.01); A61K 31/222 (2006.01); C07C 215/20 (2006.01); C07C 217/20 (2006.01); C07C 217/60 (2006.01); C07C 217/62 (2006.01); C07C 217/64 (2006.01); C07C 217/72 (2006.01); C07C 217/84 (2006.01); C07C 225/16 (2006.01); C07C 229/38 (2006.01); C07C 233/18 (2006.01); C07C 235/08 (2006.01); C07C 251/86 (2006.01); C07C 279/08 (2006.01); C07C 309/06 (2006.01); C07C 317/28 (2006.01); C07C 323/25 (2006.01); C07C 323/33 (2006.01); C07D 277/24 (2006.01); C07D 309/06 (2006.01)
CPC A61K 31/137 (2013.01) [A61K 31/165 (2013.01); A61K 31/222 (2013.01); C07C 215/20 (2013.01); C07C 217/20 (2013.01); C07C 217/60 (2013.01); C07C 217/62 (2013.01); C07C 217/64 (2013.01); C07C 217/72 (2013.01); C07C 217/84 (2013.01); C07C 225/16 (2013.01); C07C 229/38 (2013.01); C07C 233/18 (2013.01); C07C 235/08 (2013.01); C07C 251/86 (2013.01); C07C 279/08 (2013.01); C07C 309/06 (2013.01); C07C 317/28 (2013.01); C07C 323/25 (2013.01); C07C 323/33 (2013.01); C07D 277/24 (2013.01); C07D 309/06 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2601/18 (2017.05); C07C 2602/42 (2017.05)] 4 Claims
 
1. A method for treating diabetic retinopathy in a subject in need thereof comprising administering to the subject a composition comprising a compound, or stereoisomer, N-oxide or a pharmaceutically acceptable salt thereof, having the structure:

OG Complex Work Unit Chemistry