US 12,029,594 B2
Systems and methods for enhanced imaging and analysis
Uri Manor, La Jolla, CA (US); and Linjing Fang, La Jolla, CA (US)
Assigned to THE SALK INSTITUTE FOR BIOLOGICAL STUDIES, A CORPORATION OF CALIFORNIA, La Jolla, CA (US)
Appl. No. 17/269,986
Filed by THE SALK INSTITUTE FOR BIOLOGICAL STUDIES, La Jolla, CA (US)
PCT Filed Aug. 21, 2019, PCT No. PCT/US2019/047570
§ 371(c)(1), (2) Date Feb. 19, 2021,
PCT Pub. No. WO2020/041517, PCT Pub. Date Feb. 27, 2020.
Claims priority of provisional application 62/720,762, filed on Aug. 21, 2018.
Prior Publication US 2021/0321963 A1, Oct. 21, 2021
Int. Cl. A61B 6/42 (2024.01); A61B 6/00 (2006.01); A61B 6/40 (2024.01); G06T 11/00 (2006.01)
CPC A61B 6/4258 (2013.01) [A61B 6/4035 (2013.01); A61B 6/5282 (2013.01); A61B 6/5288 (2013.01); A61B 6/542 (2013.01); G06T 11/00 (2013.01); G06T 2210/41 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for collecting an image from a cellular or tissue sample, comprising:
selecting a radiation level for a first probe to meet a desired radiation dosage;
providing, with the first probe, a first radiation amount at a first selected point within a region of the sample, based on the radiation level;
associating the first selected point with at least the portion of a first emitted radiation resulting from an interaction of the first radiation amount with the sample, to form a first datum;
identifying a second selected point within the region of the sample based on a down sampling scheme;
providing, with the first probe, a second radiation amount at the second selected point within the region of the sample;
associating the second selected point with at least the portion of a second emitted radiation resulting from the interaction of the second radiation amount with the sample, to form a second datum;
interpolating the first datum and the second datum based on an up sampling scheme to obtain at least a third datum;
obtaining a plurality of data from multiple selected points in a portion of the region of the sample; and
forming an image of the region of the sample with the plurality of data.