US 12,029,552 B2
Direct infrared analysis of post-translational modification of proteins
Joris Delanghe, Aalst (BE); Marijn Speeckaert, Waasmunster (BE); Tinne Monteyne, Melsen (BE); and Thomas De Beer, Bachte (BE)
Assigned to UNIVERSITEIT GENT, Ghent (BE)
Appl. No. 16/082,113
Filed by UNIVERSITEIT GENT, Ghent (BE)
PCT Filed Mar. 6, 2017, PCT No. PCT/EP2017/055229
§ 371(c)(1), (2) Date Sep. 4, 2018,
PCT Pub. No. WO2017/153359, PCT Pub. Date Sep. 14, 2017.
Claims priority of application No. 16158854 (EP), filed on Mar. 6, 2016.
Prior Publication US 2019/0117134 A1, Apr. 25, 2019
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); G01N 21/35 (2014.01)
CPC A61B 5/14532 (2013.01) [A61B 5/0075 (2013.01); A61B 5/4842 (2013.01); A61B 5/4848 (2013.01); A61B 5/4866 (2013.01); G01N 21/35 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method for measuring post-translational modification of proteins in a subject, the method comprising:
measuring and recording of infrared radiation within a predetermined wavenumber range on a nail plate of the subject, wherein said nail plate is still attached to said subject, the infrared radiation being attenuated by nail plate protein glycation in the nail plate;
comparing said attenuation of infrared radiation to a predetermined value for deriving information regarding post-translational modification of proteins in the nail plate;
wherein said comparing comprises comparing a contribution of different spectral bands within a range of 4000 cm−1 to 4500 cm−1; and
deriving a degree of glycemia in the subject based on said comparison of the contribution of different spectral bands within the range of 4000 cm−1 to 4500 cm−1,
wherein said attenuation of infrared radiation comprises attenuation by post-translational modified integument protein in said nail, said protein being a keratin.