US 12,029,548 B2
Device for selective collection and condensation of exhaled breath
Jacqueline C. Linnes, West Lafayette, IN (US); Divya Tankasala, West Lafayette, IN (US); Shubhankar S. Takle, West Lafayette, IN (US); Orlando S. Hoilett, West Lafayette, IN (US); Gabriel P. Ng, West Lafayette, IN (US); and Michael S. Smith, West Lafayette, IN (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Appl. No. 17/251,254
Filed by Purdue Research Foundation, West Lafayette, IN (US)
PCT Filed Jun. 18, 2019, PCT No. PCT/US2019/037631
§ 371(c)(1), (2) Date Dec. 11, 2020,
PCT Pub. No. WO2020/009798, PCT Pub. Date Jan. 9, 2020.
Claims priority of provisional application 62/693,001, filed on Jul. 2, 2018.
Prior Publication US 2021/0251514 A1, Aug. 19, 2021
Int. Cl. A61B 5/097 (2006.01); A61B 5/08 (2006.01); A61B 5/145 (2006.01)
CPC A61B 5/097 (2013.01) [A61B 5/082 (2013.01); A61B 5/14532 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A device for selective collection of exhaled breath condensate, wherein the device comprises:
a) mouthpiece configured to receive an exhaled breath from a human subject, wherein the exhaled breath comprises a first portion that is not deep lung air and a second portion that is deep lung air, wherein the deep lung air comprises at least one chemical to be detected;
b) a first output configured to release the first portion of the exhaled breath that is not deep lung air;
c) a second output configured to collect the second portion of the exhaled breath that is deep lung air, wherein the deep lung air comprises at least one chemical to be detected;
d) a sensor for detecting a temperature;
e) a valve, which is connected to the mouthpiece, the first output and the second output, wherein the valve is actuated by a temperature-based algorithm to selectively release the first portion of the exhaled breath, and selectively collect the second portion of the exhaled breath, wherein the valve opens into the second output when the difference between a current breath temperature and a breath temperature at the start of the exhalation period exceeds a calculated temperature threshold, and the valve closes after two successive decreases in the breath temperature, wherein the temperature threshold is calculated based on a temperature range of the last three breaths of the human subject; and
f) a collection unit comprising a frame including (i) a plate, which is connected to the second output connected to the valve, (ii) a condensation plate, and (iii) a wiper, wherein the collection unit is configured to collect and condense the second portion of the exhaled breath and the wiper wipes the liquid from the collection unit.