US 12,029,492 B2
System and method for measuring intraocular pressure and ocular tissue biomechanical properties
Kirill V. Larin, Friendswood, TX (US); Manmohan Singh, Houston, TX (US); Jiasong Li, Pearland, TX (US); Zhaolong Han, Shanghai (CN); and Michael D. Twa, Birmingham, AL (US)
Assigned to UNIVERSITY OF HOUSTON SYSTEM, Houston, TX (US)
Filed by University of Houston System, Houston, TX (US)
Filed on Dec. 1, 2022, as Appl. No. 18/072,838.
Application 18/072,838 is a continuation of application No. 16/228,979, filed on Dec. 21, 2018, granted, now 11,553,839.
Application 16/228,979 is a continuation of application No. PCT/US2017/038799, filed on Jun. 22, 2017.
Claims priority of provisional application 62/353,398, filed on Jun. 22, 2016.
Prior Publication US 2023/0210371 A1, Jul. 6, 2023
Int. Cl. A61B 3/16 (2006.01); A61B 3/10 (2006.01); A61B 3/107 (2006.01); A61B 3/18 (2006.01); A61B 5/00 (2006.01)
CPC A61B 3/165 (2013.01) [A61B 3/102 (2013.01); A61B 3/18 (2013.01); A61B 5/0066 (2013.01); A61B 5/7246 (2013.01); A61B 5/7289 (2013.01); A61B 3/107 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A system for measuring intraocular pressure, ocular tissue geometry and biomechanical properties of an ocular tissue, comprising:
in one instrument,
a phase-sensitive swept source optical coherence tomography subsystem, wherein the phase-sensitive swept source optical coherence tomography subsystem comprises optical coherence elastography functionality, a means for delivering a focused micro air-puff to the ocular tissue, and a means for scanning and imaging the ocular tissue with micrometer-scale spatial resolution, subnanometer displacement sensitivity and microsecond-scale temporal resolution; and
an applanation tonometer subsystem in electronic communication with the phase-sensitive swept source optical coherence tomography subsystem, wherein the applanation tonometer subsystem comprises:
means for delivering an air-puff to the ocular tissue,
means for measuring a temporal pressure profile from deformation and applanation of the ocular tissue from the air-puff delivered thereto, and
means for calculating an intraocular pressure from the temporal pressure profile and spatio-temporally imaged ocular tissue deformation and applanation.