US 11,698,373 B2
Proteomic assay using quantum sensors
Jason Paul Cleveland, Boulder, CO (US); Karoly Holczer, Los Angeles, CA (US); and Barry Patrick John Vant-Hull, Boulder, CO (US)
Assigned to SomaLogic Operating Co., Inc., Boulder, CO (US)
Filed by SomaLogic Operating Co., Inc., Boulder, CO (US)
Filed on Feb. 15, 2022, as Appl. No. 17/672,089.
Application 17/672,089 is a continuation of application No. 16/686,911, filed on Nov. 18, 2019, granted, now 11,249,080.
Application 16/686,911 is a continuation of application No. 15/917,524, filed on Mar. 9, 2018, granted, now 10,481,155, issued on Nov. 19, 2019.
Prior Publication US 2022/0170927 A1, Jun. 2, 2022
Int. Cl. G01N 33/543 (2006.01); G01N 33/68 (2006.01); G01N 33/487 (2006.01); G01N 24/08 (2006.01); G01R 33/32 (2006.01); G01N 21/78 (2006.01); G01N 21/64 (2006.01); G01N 33/53 (2006.01); G01N 21/77 (2006.01)
CPC G01N 33/54386 (2013.01) [G01N 21/64 (2013.01); G01N 21/78 (2013.01); G01N 24/088 (2013.01); G01N 33/487 (2013.01); G01N 33/5308 (2013.01); G01N 33/54306 (2013.01); G01N 33/6803 (2013.01); G01R 33/323 (2013.01); G01N 21/6489 (2013.01); G01N 2021/6495 (2013.01); G01N 2021/7783 (2013.01); G01N 2570/00 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for measuring a concentration of label-free target molecules in a sample fluid, the method comprising:
exposing a substrate to a sample fluid such that a plurality of capture reagents attached to a surface of the substrate contact the sample fluid, the plurality of capture reagents including first capture reagents configured to bind to first label-free target molecules and second capture reagents configured to bind to second label-free target molecules different from the first label-free target molecules;
detecting, based on emission of electromagnetic radiation from at least one color center within the substrate, a change in a property of the at least one color center in response to binding between the first label-free target molecules and the first capture reagents; and
determining, based on the detected change, a concentration of the first label-free target molecules within the sample fluid.