US 11,698,372 B2
Near infrared fluorescent biosensors for steroid hormones
Michael Strano, Lexington, MA (US); Michael Lee, Carteret, NJ (US); Naveed Bakh, Lexington, KY (US); and Song Wang, Cambridge, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US)
Filed on May 4, 2020, as Appl. No. 16/866,091.
Claims priority of provisional application 62/843,544, filed on May 5, 2019.
Prior Publication US 2020/0348291 A1, Nov. 5, 2020
Int. Cl. G01N 33/543 (2006.01); G01N 33/74 (2006.01); A61B 5/145 (2006.01); A61B 5/1459 (2006.01)
CPC G01N 33/5436 (2013.01) [G01N 33/54393 (2013.01); G01N 33/743 (2013.01); A61B 5/1459 (2013.01); A61B 5/14546 (2013.01); A61B 2562/0238 (2013.01); A61B 2562/0285 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A composition, comprising:
a complex, wherein the complex includes:
a nanostructure; and
a polymer, the polymer adsorbed on the nanostructure and the polymer being free from selective binding to an analyte in the absence of being adsorbed on the nanostructure, wherein the polymer is a heteropolymer including a hydrophobic region and a hydrophilic region and the polymer includes a template moiety; and
a selective binding site associated with the complex, the selectivity of the selective binding site being dependent on the template moiety.