CPC C07K 16/2827 (2013.01) [C12N 15/85 (2013.01); G01N 33/5695 (2013.01); G01N 33/57492 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); G01N 2800/26 (2013.01)] | 13 Claims |
1. A method to diagnose cancer and/or infection comprising contacting in vitro one or more cells from a subject with an antibody; and
determining if said antibody binds to said one or more cells,
wherein increased binding to said cells as compared to a control is indicative of cancer and/or infection,
wherein the cancer is a cancer where cancer cells express PD-L1,
wherein the infection is an infection where infected cells express PD-L1, and
wherein said antibody is an anti-PD-L1 antibody comprising
(a) a light chain comprising CDR1 having the amino acid sequence of KSISKY (SEQ ID NO: 1), CDR2 having the amino acid sequence of SGS and CDR3 having the amino acid sequence of QQHNEYPLT (SEQ ID NO: 2) and
(b) a heavy chain comprising CDR1 having the amino acid sequence of GYTFTDYI (SEQ ID NO: 3), CDR2 having the amino acid sequence of INPDSGGN (SEQ ID NO: 4) and CDR3 having the amino acid sequence of ARGITMMVVISHWKFDF (SEQ ID NO: 5),
wherein said antibody binds ovine, bovine, porcine or canine PD-L1 proteins, and
wherein the cancer is not malignant melanoma.
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