US 11,697,675 B2
EPHA3 and multi-valent targeting of tumors
Waldemar Debinski, Winston-Salem, NC (US); Carla Lema Tome, Winston-Salem, NC (US); Sara Ferluga, Trieste (IT); and Poonam S. Sonawane, Winston-Salem, NC (US)
Assigned to Wake Forest University Health Sciences, Winston-Salem, NC (US)
Filed by Wake Forest University Health Sciences, Winston-Salem, NC (US)
Filed on Jul. 21, 2020, as Appl. No. 16/947,154.
Application 16/947,154 is a division of application No. 15/958,608, filed on Apr. 20, 2018, granted, now 10,752,667.
Application 15/958,608 is a division of application No. 15/035,560, granted, now 9,975,942, issued on May 22, 2018, previously published as PCT/US2014/064983, filed on Nov. 11, 2014.
Claims priority of provisional application 62/036,262, filed on Aug. 12, 2014.
Claims priority of provisional application 61/902,568, filed on Nov. 11, 2013.
Prior Publication US 2020/0347113 A1, Nov. 5, 2020
Int. Cl. C07K 14/705 (2006.01); C07K 14/52 (2006.01); A61K 38/00 (2006.01); C07K 14/54 (2006.01); G01N 33/574 (2006.01)
CPC C07K 14/705 (2013.01) [C07K 14/52 (2013.01); C07K 14/5437 (2013.01); G01N 33/57492 (2013.01); A61K 38/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/06 (2013.01); C07K 2319/09 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/55 (2013.01); C07K 2319/74 (2013.01)] 28 Claims
 
1. A nucleic acid that encodes a polypeptide construct having a formula from N terminus to C terminus of: F-G-H, or H-G-F
wherein: F is a ligand that binds to all three of EphA2, EphA3 and EphB2; G is a peptide linker; and H is a ligand that binds to IL-13Rα2.