CPC C07D 471/04 (2013.01) | 61 Claims |
1. A compound of Formula (I):
or a pharmaceutically acceptable salt, stereoisomer, solvate, or tautomer thereof,
wherein:
Ring A is selected from aryl or heteroaryl;
each R1 is independently selected from halo, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, aryl, —C(O)OR4, and —C(O)NR5R6, wherein aryl is optionally substituted with one or more R7;
R2 is selected from H, C1-C6 alkyl, and —C(O)R4;
R3 is selected from 3- to 8-membered heterocyclyl, —O(CH2O)oR8, and —N(R9)2, wherein the heterocyclyl is optionally substituted with one or more R10;
each R4 is independently selected from H and C1-C6 alkyl;
each R5 is independently selected from H, C1-C6 alkyl, —(CH2)pOR11, —(CH2)pN(R11)2, and S(O)2R11;
each R6 is independently selected from H and C1-C6 alkyl,
or R5 and R6, together with the atom to which they are attached, come together to form a 3- to 10-membered heterocyclyl ring further comprising 1, 2, or 3 heteroatoms selected from N, O, and S, wherein the heterocyclyl is optionally substituted with one or more R11;
each R7 is independently selected from halo, —OH, —CN, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, and C1-C6 haloalkoxy;
R8 is selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, and 3- to 8-membered heterocyclyl, wherein the heterocyclyl is optionally substituted with one or more R10;
each R9 is independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl;
each R10 is independently selected from C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo, and —OH;
each R11 is independently selected from H and C1-C6 alkyl;
m is an integer selected from 0, 1, 2, 3, 4, and 5; and
n is an integer selected from 0, 1, 2, 3, and 4;
o is an integer selected from 0, 1, and 2; and
p is an integer selected from 0, 1, 2, 3, 4, 5, and 6.
|