US 11,696,955 B2
Drug-polymer conjugate
Stephen Lonsdale Birkett, Victoria (AT); Andrew Craig Donohue, Bentleigh East (AU); Asha Marina D'Souza, Carnegie (AU); Sarah Man Yee Ng, Berwick (AU); Adrian Sulistio, Glen Iris (AU); Russell John Tait, Balwyn (AU); David Valade, Glenroy (AU); Alan Naylor, Harston (GB); and Jason Watling, Gisborne (AU)
Assigned to POLYACTIVA PTY LTD, Melbourne (AU)
Filed by POLYACTIVA PTY LTD, Melbourne (AU)
Filed on Dec. 23, 2021, as Appl. No. 17/561,126.
Application 17/561,126 is a continuation of application No. 16/493,258, granted, now 11,207,417, previously published as PCT/AU2018/050233, filed on Mar. 14, 2018.
Application 16/493,258 is a continuation in part of application No. 15/458,546, filed on Mar. 14, 2017, granted, now 10,113,033.
Claims priority of application No. 2017900888 (AU), filed on Mar. 14, 2017.
Prior Publication US 2022/0226483 A1, Jul. 21, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/5575 (2006.01); A61K 47/50 (2017.01); A61K 47/59 (2017.01); A61P 27/02 (2006.01)
CPC A61K 47/593 (2017.08) [A61K 31/5575 (2013.01); A61P 27/02 (2018.01)] 15 Claims
 
1. A polymer-prostaglandin conjugate comprising:
a polymer backbone comprising a plurality of moieties of formula (I):

OG Complex Work Unit Chemistry
where:
T represents a triazole moiety;
Q is independently selected at each occurrence and may be present or absent and when present represents a linking group;
R is selected from the group consisting of linear and branched hydrocarbons;
D is a prostaglandin analogue of formula (Xb)

OG Complex Work Unit Chemistry
wherein:
custom character represents the point of attachment of the prostaglandin analogue to L;
custom character represents a double or single bond;
Y is optionally substituted C4 to C10 hydrocarbyl or optionally substituted C4 to C10 hydrocarbyloxy;
R9 and R11 are hydroxy; and
W is hydroxy and U is hydrogen, or W and U are both fluoro, or W and U together form oxo; and
L is a group of formula (II)

OG Complex Work Unit Chemistry
wherein R5 is selected from hydrogen and C1 to C6 alkyl;
(R) indicates the end of the group bonded to the R group; and
(D) indicates the end of the group attached to the group D.