CPC A61K 47/593 (2017.08) [A61K 31/5575 (2013.01); A61P 27/02 (2018.01)] | 15 Claims |
1. A polymer-prostaglandin conjugate comprising:
a polymer backbone comprising a plurality of moieties of formula (I):
where:
T represents a triazole moiety;
Q is independently selected at each occurrence and may be present or absent and when present represents a linking group;
R is selected from the group consisting of linear and branched hydrocarbons;
D is a prostaglandin analogue of formula (Xb)
wherein:
represents the point of attachment of the prostaglandin analogue to L;
represents a double or single bond;
Y is optionally substituted C4 to C10 hydrocarbyl or optionally substituted C4 to C10 hydrocarbyloxy;
R9 and R11 are hydroxy; and
W is hydroxy and U is hydrogen, or W and U are both fluoro, or W and U together form oxo; and
L is a group of formula (II)
wherein R5 is selected from hydrogen and C1 to C6 alkyl;
(R) indicates the end of the group bonded to the R group; and
(D) indicates the end of the group attached to the group D.
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