US 11,696,935 B2
Phosphorylcholine conjugates and uses thereof
Yehuda Shoenfeld, Ramat Gan (IL); and Miriam Blank, Tel Aviv (IL)
Assigned to TPCERA LTD., Jerusalem (IL)
Filed by TPCERA LTD., Jerusalem (IL)
Filed on Nov. 23, 2020, as Appl. No. 17/101,471.
Application 17/101,471 is a continuation of application No. 16/101,781, filed on Aug. 13, 2018, granted, now 10,842,844.
Application 16/101,781 is a continuation of application No. 15/991,335, filed on May 29, 2018, granted, now 10,881,707.
Application 16/101,781 is a continuation of application No. 14/956,167, filed on Dec. 1, 2015, granted, now 10,046,021, issued on Aug. 14, 2018.
Application 15/991,335 is a continuation of application No. 14/956,167, filed on Dec. 1, 2015, granted, now 10,046,021, issued on Aug. 14, 2018.
Application 14/956,167 is a continuation in part of application No. 14/766,108, granted, now 9,987,372, issued on Jun. 5, 2018, previously published as PCT/IL2014/050124, filed on Feb. 5, 2014.
Claims priority of provisional application 61/760,668, filed on Feb. 5, 2013.
Prior Publication US 2021/0161992 A1, Jun. 3, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/08 (2019.01); A61K 38/07 (2006.01); A61K 47/64 (2017.01); A61K 47/54 (2017.01)
CPC A61K 38/07 (2013.01) [A61K 38/08 (2013.01); A61K 47/544 (2017.08); A61K 47/548 (2017.08); A61K 47/64 (2017.08); A61K 47/646 (2017.08)] 14 Claims
 
1. A method for preventing or treating uveitis in a subject in need thereof, the method comprising administering to the subject a composition comprising at least one phosphorylcholine moiety or a derivative thereof comprising phosphorylcholine covalently bound directly to the C-terminus of an amino-acid sequence whose C-terminus consists of TKPRGY (SEQ ID NO: 25), and wherein
a. said phosphorylcholine derivative is any one of 4-amino-phenyl-phosphocholine, 4-diazonio-phenyl-phosphorylcholine, 4-nitro-phenyl-phosphocholine and 12-(3-iodophenyl)dodecyl-phosphocholine;
b. said phosphorylcholine moiety or a derivative thereof is bound to said C-terminus by an azo-bond; or
c. both a and b;
thereby preventing or treating the uveitis in the subject.