CPC A61K 31/7088 (2013.01) [A61K 9/1075 (2013.01); A61K 9/127 (2013.01); A61K 9/5146 (2013.01); A61K 31/713 (2013.01); A61K 47/10 (2013.01); A61K 47/183 (2013.01); A61K 47/60 (2017.08); A61K 47/6455 (2017.08); A61K 47/6935 (2017.08); A61P 35/00 (2018.01); B82Y 5/00 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/351 (2013.01); C12N 2320/30 (2013.01); C12N 2320/32 (2013.01)] | 10 Claims |
1. A method for making a construct comprising:
(a) conjugating a maleimide-containing gastrin peptide with a block copolymer resulting in a nanoparticle, the block copolymer comprising (i) a thiol-functionalized polyethylene glycol block and (ii) a poly(L-lysine) block; and
(b) mixing the resulting nanoparticle with at least one siRNA.
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