US 11,696,922 B2
Nanoparticle to target cancer
Jill P. Smith, Washington, DC (US); Stephan Stern, Frederick, MD (US); and Abdullah Mahmud, Frederick, MD (US)
Assigned to Georgetown University, Washington, DC (US); and The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
Filed by Georgetown University, Washington, DC (US); and The United States of America, as represented by the Secretary, Department of Health & Human Services, Bethesda, MD (US)
Filed on Dec. 17, 2021, as Appl. No. 17/555,285.
Application 17/555,285 is a division of application No. 16/084,942, granted, now 11,246,881, previously published as PCT/US2017/022567, filed on Mar. 15, 2017.
Claims priority of provisional application 62/309,250, filed on Mar. 16, 2016.
Prior Publication US 2022/0211738 A1, Jul. 7, 2022
Int. Cl. C07H 21/02 (2006.01); A61K 31/7088 (2006.01); C12N 15/115 (2010.01); A61K 47/10 (2017.01); A61K 47/18 (2017.01); A61K 9/107 (2006.01); A61K 9/51 (2006.01); C12N 15/11 (2006.01); A61K 47/60 (2017.01); A61K 47/64 (2017.01); A61K 47/69 (2017.01); A61K 31/713 (2006.01); C12N 15/113 (2010.01); A61P 35/00 (2006.01); A61K 9/127 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 31/7088 (2013.01) [A61K 9/1075 (2013.01); A61K 9/127 (2013.01); A61K 9/5146 (2013.01); A61K 31/713 (2013.01); A61K 47/10 (2013.01); A61K 47/183 (2013.01); A61K 47/60 (2017.08); A61K 47/6455 (2017.08); A61K 47/6935 (2017.08); A61P 35/00 (2018.01); B82Y 5/00 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/351 (2013.01); C12N 2320/30 (2013.01); C12N 2320/32 (2013.01)] 10 Claims
 
1. A method for making a construct comprising:
(a) conjugating a maleimide-containing gastrin peptide with a block copolymer resulting in a nanoparticle, the block copolymer comprising (i) a thiol-functionalized polyethylene glycol block and (ii) a poly(L-lysine) block; and
(b) mixing the resulting nanoparticle with at least one siRNA.