US 11,696,896 B2
Immunomodulatory nanoparticle treatment of brain injury
John A. Kessler, Evanston, IL (US); and Sripadh B. Sharma, Chicago, IL (US)
Assigned to Northwestern University, Evanston, IL (US)
Filed by Northwestern University, Evanston, IL (US)
Filed on Oct. 21, 2020, as Appl. No. 17/76,235.
Claims priority of provisional application 62/924,849, filed on Oct. 23, 2019.
Prior Publication US 2021/0121413 A1, Apr. 29, 2021
Int. Cl. A61K 9/51 (2006.01); A61K 9/00 (2006.01)
CPC A61K 9/5153 (2013.01) [A61K 9/0019 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method of treating traumatic brain injury in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of nanoparticles consisting essentially of poly(lactic-co-glycolic acid) (PLGA); wherein the nanoparticles are free of any attached or embedded peptide, antigen, or other active agent; and the nanoparticles are administered intravenously.