CPC A61B 5/0275 (2013.01) [A61B 5/0071 (2013.01); A61B 5/0295 (2013.01); A61B 5/6826 (2013.01)] | 33 Claims |
1. A method for quantifying absolute blood flow through a tissue volume, comprising:
administering a volume of a fluorescence dye into the vasculature supplying the tissue volume;
obtaining a sequence of angiographic images of the tissue volume;
calculating average fluorescence intensities for the sequence of angiographic images of the tissue volume;
generating a plot of time-varying average fluorescence intensity;
determining an increase in thickness of a blood volume layer based on the plot of time-varying average fluorescence intensity and based on a graph of fluorescence intensity versus capillary diameter; and
determining absolute blood flow based in part on the determined increase in thickness of the blood volume layer.
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