US 12,354,708 B2
Analysis method of analyzing a nucleic acid sequence, and a system that analyzes a nucleic acid sequence
Kenichiro Suzuki, Kobe (JP); Reiko Watanabe, Kobe (JP); Mizuho Kawate, Kobe (JP); Kosuke Kai, Kobe (JP); and Hiroko Onoe, Kobe (JP)
Assigned to SYSMEX CORPORATION, Kobe (JP)
Filed by SYSMEX CORPORATION, Kobe (JP)
Filed on Jun. 19, 2020, as Appl. No. 16/906,475.
Claims priority of application No. 2019-114139 (JP), filed on Jun. 19, 2019.
Prior Publication US 2020/0402612 A1, Dec. 24, 2020
Int. Cl. G16B 20/20 (2019.01); C12Q 1/6869 (2018.01); C12Q 1/6883 (2018.01); C12Q 1/6886 (2018.01); G06F 40/174 (2020.01); G16B 30/00 (2019.01); G16H 15/00 (2018.01)
CPC G16B 20/20 (2019.02) [C12Q 1/6869 (2013.01); C12Q 1/6883 (2013.01); C12Q 1/6886 (2013.01); G06F 40/174 (2020.01); G16B 30/00 (2019.02); G16H 15/00 (2018.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01)] 17 Claims
 
1. An analysis method of analyzing a nucleic acid sequence derived from a patient sample with a computer, the computer configured with instructions to perform operations comprising:
obtaining from a storage device or a sequencer coupled to the computer, nucleic acid sequence data related to the nucleic acid sequence derived from the patient sample and reference sequence data;
determining a presence of a mutation by:
comparing the obtained nucleic acid sequence data with the reference sequence data;
identifying whether a rate of coincidence between the nucleic acid sequence data and the reference sequence data satisfies a predetermined criteria; and
generating an analysis result based on the comparison;
receiving a selection from among candidate forms each for the same patient associated with the patient sample, the candidate forms comprising a first form and a second form different from the first form, for providing a report of information of the patient and the analysis result based on the determination of the presence of the mutation; and
generating, based on the received selection being the first form, a first report of the analysis result providing information relating to the determined mutation in the first form which is different from the second form, and generating based on the received selection being the second form, a second report of the analysis result providing information relating to the determined mutation in the second form which is different from the first form, wherein
the second report includes the information of the patient and provides information relating to a germline mutation among the determined mutation in the second form, and
the first report includes the information of the patient and does not provide at least part of the information relating to the germline mutation.