US 12,352,947 B2
Microscope and related apparatuses, methods, and computer programs
George Themelis, Lindau (DE)
Assigned to Leica Instruments (Singapore) Pte Ltd., Singapore (SG)
Appl. No. 17/754,615
Filed by Leica Instruments (Singapore) Pte. Ltd., Singapore (SG)
PCT Filed Oct. 7, 2020, PCT No. PCT/EP2020/078153
§ 371(c)(1), (2) Date Apr. 7, 2022,
PCT Pub. No. WO2021/069512, PCT Pub. Date Apr. 15, 2021.
Claims priority of application No. 19202503 (EP), filed on Oct. 10, 2019.
Prior Publication US 2022/0365331 A1, Nov. 17, 2022
Int. Cl. G02B 21/36 (2006.01); G01N 21/64 (2006.01); G02B 21/06 (2006.01); G02B 21/16 (2006.01); G02B 21/18 (2006.01); G02B 27/14 (2006.01); H04N 23/45 (2023.01); H04N 23/56 (2023.01); H04N 23/667 (2023.01)
CPC G02B 21/367 (2013.01) [G01N 21/6458 (2013.01); G01N 21/6486 (2013.01); G02B 21/06 (2013.01); G02B 21/16 (2013.01); G02B 21/18 (2013.01); G02B 27/141 (2013.01); H04N 23/45 (2023.01); H04N 23/56 (2023.01); H04N 23/667 (2023.01)] 14 Claims
OG exemplary drawing
 
1. A microscope comprising:
a light emission module for providing illumination for a sample of organic tissue in a plurality of wavelength bands;
a first imaging sensor module and a second imaging sensor module configured to independently sense light in a plurality of mutually separated non-continuous wavelength bands, wherein the first imaging sensor module is configured to independently sense light in each wavelength band of a third subset of wavelength bands of the plurality of mutually separated non-continuous wavelength bands, and wherein the second imaging sensor module is configured to independently sense light in each wavelength band of a fourth subset of wavelength bands of the plurality of mutually separated non-continuous wavelength bands, wherein each of the third and fourth subset of wavelength bands comprises two or more mutually separated non-continuous wavelength bands; and
a processing module configured to:
control the light emission module such that in a first operating mode light in a first subset of two or more mutually separated non-continuous wavelength bands is emitted towards the sample of organic tissue, and that in a second operating mode light in a second subset of two or more mutually separated non-continuous wavelength bands is emitted towards the sample of organic tissue, the first and second subset of two or more mutually separated non-continuous wavelength bands being at least partially different, and
use the first and second imaging sensor modules to perform reflectance imaging and fluorescence imaging in each of the third and fourth subset of the plurality of mutually separated non-continuous wavelength bands based on the light emitted in the first and second operating modes.