US 12,352,743 B2
Tension measuring device
Hodaka Makino, Tokorozawa (JP); and Tetsuya Ogawa, Tokorozawa (JP)
Assigned to NIHON KOHDEN CORPORATION, Tokyo (JP)
Filed by NIHON KOHDEN CORPORATION, Tokyo (JP)
Filed on Mar. 8, 2021, as Appl. No. 17/194,682.
Claims priority of application No. 2020-045693 (JP), filed on Mar. 16, 2020.
Prior Publication US 2021/0285935 A1, Sep. 16, 2021
Int. Cl. G01N 33/50 (2006.01); G01N 33/483 (2006.01)
CPC G01N 33/5061 (2013.01) [G01N 33/483 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A tension measuring device, comprising:
a holder that holds a cell structure including muscle cells;
a first container including a culture medium and the holder, the cell structure being immersed in the culture medium;
a second container including a medical agent;
a first tube which links the first container and the second container liquidtightly;
a pump which is disposed over the first tube and causes liquid to flow into the first container from the second container; and
a load cell linked to the holder and configured to measure a tension of the cell structure including muscle cells,
wherein the first tube is connected to a lateral surface of the first container at a position entirely immersed in the culture medium, and
wherein the first tube is connected to the first container at a position that is offset from a center line when the first container is seen from above in a vertical direction.
 
3. A tension measuring device, comprising:
a holder that holds a cell structure including muscle cells;
a first container including a culture medium and the holder, the cell structure being immersed in the culture medium;
a second container including a medical agent;
a first tube which links the first container and the second container liquidtightly;
a pump which is disposed over the first tube and causes liquid to flow into the first container from the second container; and
a load cell linked to the holder and configured to measure a tension of the cell structure including muscle cells,
wherein the first tube is connected to a lateral surface of the first container,
wherein the first tube is connected to the first container at a position that is offset from a center line when the first container is seen from above in a vertical direction,
wherein the first tube branches into plural tubes in a vertical direction at a position where the first tube is connected to the first container.
 
7. A tension measuring device, comprising:
a holder that holds a cell structure including muscle cells;
a first container including a culture medium and the holder, the cell structure being immersed in the culture medium;
a second container including a medical agent;
a first tube which links the first container and the second container liquidtightly;
a pump which is disposed over the first tube and causes liquid to flow into the first container from the second container;
a load cell linked to the holder and configured to measure a tension of the cell structure including muscle cells;
a second tube which links the first container and the second container liquidtightly; and
an inflow pump which is disposed over the second tube and causes liquid to flow into the second container from the first container,
wherein the first tube is connected to a lateral surface of the first container, and
wherein the first tube is connected to the first container at a position that is offset from a center line when the first container is seen from above in a vertical direction.