US 12,352,695 B2
System and method for monitoring the health of dialysis patients
John L. Robertson, Floyd, VA (US); Ryan Senger, North Chesterfield, VA (US); and Pang Du, Blacksburg, VA (US)
Assigned to Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US)
Filed by Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US)
Filed on Mar. 16, 2023, as Appl. No. 18/122,180.
Application 18/122,180 is a continuation of application No. 15/305,940, granted, now 11,674,903, previously published as PCT/US2015/027323, filed on Apr. 23, 2015.
Claims priority of provisional application 61/983,038, filed on Apr. 23, 2014.
Prior Publication US 2023/0243752 A1, Aug. 3, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/65 (2006.01); A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61M 1/14 (2006.01); A61M 1/16 (2006.01); A61M 1/28 (2006.01); A61M 1/36 (2006.01); G01N 33/49 (2006.01); G16H 10/40 (2018.01); G16H 20/40 (2018.01)
CPC G01N 21/65 (2013.01) [A61B 5/0075 (2013.01); A61B 5/14525 (2013.01); A61B 5/6866 (2013.01); A61M 1/14 (2013.01); A61M 1/1609 (2014.02); A61M 1/1619 (2014.02); A61M 1/1692 (2013.01); A61M 1/282 (2014.02); A61M 1/3609 (2014.02); G01N 33/492 (2013.01); G16H 10/40 (2018.01); G16H 20/40 (2018.01); A61M 2205/3313 (2013.01); A61M 2205/50 (2013.01); A61M 2205/52 (2013.01); G01N 21/658 (2013.01); G01N 2570/00 (2013.01)] 12 Claims
 
1. A method comprising:
subjecting a patient to an initial dialysis treatment;
obtaining multiple urine and/or dialysate samples associated with the patient;
providing a Raman spectrum for each of the multiple samples associated with the patient;
detecting a molecular fingerprint of four or more analytes relative to one another in each of the Raman spectra and therefrom establishing analyte clearance kinetics indicative of progress of the dialysis treatment; and
treating the patient with one or more subsequent dialysis treatment(s) dependent on a disease state associated with the analyte clearance kinetics represented from the multiple samples of the patient;
wherein the subsequent dialysis treatment(s) is/are:
modified relative to the initial dialysis treatment; and
performed for a time, rate, and/or frequency based on the analyte clearance kinetics.