	US 12,351,857 B2
	Activity based probes
Satpal Virdee, Dundee (GB); Sunil Mathur, Dundee (GB); and Adam Fletcher, Dundee (GB)
Assigned to University of Dundee, Dundee (GB)
Appl. No. 17/753,324
Filed by University of Dundee, Dundee (GB)
PCT Filed Aug. 28, 2020, PCT No. PCT/EP2020/074069 § 371(c)(1), (2) Date Feb. 28, 2022, PCT Pub. No. WO2021/038034, PCT Pub. Date Mar. 4, 2021.
Claims priority of application No. 1912339 (GB), filed on Aug. 28, 2019; and application No. 1916504 (GB), filed on Nov. 13, 2019.
Prior Publication US 2022/0267825 A1, Aug. 25, 2022
Int. Cl. C12Q 1/48 (2006.01); C12N 9/00 (2006.01); C12N 9/10 (2006.01)

CPC C12Q 1/48 (2013.01) [C12N 9/104 (2013.01); G01N 2333/9108 (2013.01)]

18 Claims

1. A conjugate molecule comprising an activated ubiquitin molecule of SEQ ID NO: 1 comprising a photocrosslinker moiety in place of a glutamine residue at position 31 and/or aspartic acid residue at position 32 of ubiquitin conjugated to an E2 conjugating enzyme.