US 12,351,827 B2
Systems and methods fabricating a microchannel vascular network device and seeding a microchannel
Joseph Vacanti, Winchester, MA (US); Batzaya Byambaa, Cambridge, MA (US); Carly Comer, Boston, MA (US); Matthew Hancock, Newton, MA (US); Tyler Lieberthal, Brookline, MA (US); Tatevik Sahakyants, Lexington, MA (US); Andrew Spann, Newton, MA (US); and Craig Neville, Melrose, MA (US)
Assigned to 3D BioLabs, Inc., Chadds Ford, PA (US)
Filed by 3D BioLabs, LLC, Chadds Ford, PA (US)
Filed on Jun. 18, 2020, as Appl. No. 16/905,898.
Claims priority of provisional application 62/863,169, filed on Jun. 18, 2019.
Claims priority of provisional application 62/863,165, filed on Jun. 18, 2019.
Prior Publication US 2021/0071145 A1, Mar. 11, 2021
Int. Cl. B29C 64/393 (2017.01); B33Y 50/02 (2015.01); C12M 3/06 (2006.01); C12N 5/071 (2010.01); C12N 13/00 (2006.01)
CPC C12N 5/0671 (2013.01) [B29C 64/393 (2017.08); B33Y 50/02 (2014.12); C12M 23/16 (2013.01); C12N 13/00 (2013.01); C12N 2513/00 (2013.01); C12N 2529/10 (2013.01); C12N 2533/30 (2013.01); C12N 2533/54 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of using an additive manufacture computer system for fabricating a microchannel network device, the method comprising:
(A) receiving, in electronic form, a three-dimensional model of a microchannel network device comprising an identification of: (i) the additive manufacture computer system for fabricating the microchannel network device, (ii) a media accommodated by the microchannel network device, and (iii) a pre-polymer solution utilized at the additive manufacture computer system;
(B) retrieving, from a design module, a plurality of design criteria, wherein each design criteria in the plurality of design criteria is associated with a structural limit of fabricating the microchannel network device;
(C) generating, in electronic form, based on the plurality of design criteria and the three-dimensional model of the microchannel network device, an instance of the microchannel network device, wherein the instance of the microchannel network device comprises:
a dimensionality of a first channel network,
a dimensionality of a second channel network based on the first channel network,
a structure interposing and providing fluidic communication between the first channel network and the second channel network, and
a flow rate of the media through the first channel network or the second channel network;
(D) further generating, based on the identification of the additive manufacture computer system for fabricating the microchannel network device and the pre-polymer solution, one or more instructions for forming the instance of the microchannel network device of a polymer material at the additive manufacture computer system using the pre-polymer solution; and
(E) communicating, to the additive manufacture computer system, the one or more instructions for forming the instance of the microchannel network device, thereby utilizing the additive manufacture computer system for fabricating the microchannel network device.