US 12,351,656 B2
Functionalized and crosslinked polymers
David Gravett, Mountain View, CA (US); Kara Bethany Acampora, West Union, SC (US); and Prabhjot Saini, Greenville, SC (US)
Assigned to PMIDG, LLC, Anderson, SC (US)
Filed by PMIDG, LLC, Anderson, SC (US)
Filed on Sep. 9, 2022, as Appl. No. 17/942,017.
Application 17/942,017 is a continuation of application No. 16/643,438, granted, now 11,440,976, previously published as PCT/US2018/049286, filed on Sep. 1, 2018.
Claims priority of provisional application 62/553,371, filed on Sep. 1, 2017.
Prior Publication US 2023/0312764 A1, Oct. 5, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 29/08 (2006.01); A61L 27/20 (2006.01); A61L 29/16 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01); C08B 37/08 (2006.01); B33Y 70/00 (2020.01); B33Y 80/00 (2015.01)
CPC C08B 37/0072 (2013.01) [A61L 27/20 (2013.01); A61L 29/085 (2013.01); A61L 31/10 (2013.01); A61L 29/16 (2013.01); A61L 31/16 (2013.01); B33Y 70/00 (2014.12); B33Y 80/00 (2014.12)] 18 Claims
 
1. A coating for a medical device,
comprising, a hyaluronic acid polymer derivative comprising one or more modified hydroxyl groups, wherein the hyaluronic acid polymer derivative has the formula:
A) HA-(OCH2CH2SO2CH2CH2—X—R1—Y)n, where HA is hyaluronic acid, X is S or NH, R1 is an aromatic moiety, and Y is one or more of H, a carboxylic acid group or a salt or ester thereof, a hydroxyl group, a sulfonic acid group or a salt thereof, or an amine group, and n is the number of modified hydroxyl groups where n≥1; or
B) (Y—R2—X—CH2CH2SO2CH2CH2O)m-HA-(OCH2CH2SO2CH2CH2—X—R1—Y)n, where HA is hyaluronic acid, X is S or NH, R1 and R2 are each a substituted or unsubstituted C1-C20 aliphatic or aromatic moiety, wherein R1 and R2 are different from each other, Y may be the same or different, and Y is one or more of H, a carboxylic acid group or a salt or ester thereof, a hydroxyl group, a sulfonic acid group or a salt thereof, or an amine group, and n≥1 and m≥1; or
C) (CH2═CH—SO2CH2CH2O)m-HA-(OCH2CH2SO2CH2CH2—X—R1—Y)n, where HA is hyaluronic acid, X is S or NH, R1 is a substituted or unsubstituted C1-C20 aliphatic or aromatic moiety, and Y is one or more of H, a carboxylic acid group or salt or ester thereof, a hydroxyl group, a sulfonic acid group or a salt thereof, or an amine group, and n≥1 and m≥1,
wherein the coating, when hydrated, increases the lubricity of a coated medical device.