	US 12,351,646 B2
	*Diagnostic methods using anti-MUC1 antibodies**
Cynthia Bamdad, Boston, MA (US)
Assigned to MINERVA BIOTECHNOLOGIES CORPORATION, Waltham, MA (US)
Filed by Minerva Biotechnologies Corporation, Waltham, MA (US)
Filed on Mar. 21, 2024, as Appl. No. 18/612,767.
Application 18/612,767 is a continuation of application No. 16/975,625, granted, now 11,976,132, previously published as PCT/US2019/019566, filed on Feb. 26, 2019.
Application 16/975,625 is a continuation in part of application No. PCT/US2018/062569, filed on Nov. 27, 2018.
Claims priority of provisional application 62/791,661, filed on Jan. 11, 2019.
Claims priority of provisional application 62/640,697, filed on Mar. 9, 2018.
Claims priority of provisional application 62/635,378, filed on Feb. 26, 2018.
Prior Publication US 2024/0352149 A1, Oct. 24, 2024
Int. Cl. C07K 16/30 (2006.01); A61K 35/17 (2025.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61K 47/68 (2017.01); G01N 33/574 (2006.01)

CPC C07K 16/3092 (2013.01) [A61K 35/17 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4257 (2025.01); A61K 47/6851 (2017.08); G01N 33/57492 (2013.01); C07K 2317/34 (2013.01)]

16 Claims

1. An anti-MUC1* antibody or antibody fragment comprising the following six complementarity determining regions (CDRs):

SEQ ID NOs: 144, 146, 148, 150, 152, and 154,

SEQ ID NOs: 80, 82, 84, 86, 88, and 90,

SEQ ID NOs: 112, 114, 116, 118, 120, and 122,

SEQ ID NOs: 128, 130, 132, 134, 136, and 138,

SEQ ID NOs: 160, 162, 164, 166, 168, and 170,

SEQ ID NOs: 176, 178, 180, 182, 184, and 186,

SEQ ID NOs: 192, 194, 196, 198, 200, and 202,

SEQ ID NOs: 208, 210, 212, 214, 216, and 218,

SEQ ID NOs: 224, 226, 228, 230, 232, and 234,

SEQ ID NOs: 48, 50, 52, 54, 56, and 58,

SEQ ID NOs: 64, 66, 68, 70, 72, and 74,

SEQ ID NOs: 16, 18, 20, 22, 24, and 26, or

SEQ ID NOs: 32, 34, 36, 38, 40, and 42;

wherein the six CDRs of each antibody or antibody fragment are heavy chain CDR1, heavy chain CDR2, heavy chain CDR3, light chain CDR1, light chain CDR2, and light chain CDR3, respectively.