	US 12,351,623 B2
	Antibody compositions targeting non-phosphorylated alpha-synuclein aggregates
Omar El-Agnaf, Doha (QA); Nour Khaled Majbour, Doha (QA); and Nishant Vaikath, Doha (QA)
Assigned to HAMAD BIN KHALIFA UNIVERSITY, Doha (QA)
Filed by Qatar Foundation for Education, Science and Community Development, Doha (QA)
Filed on Oct. 26, 2021, as Appl. No. 17/511,230.
Application 17/511,230 is a continuation in part of application No. PCT/QA2021/050019, filed on Sep. 17, 2021.
Claims priority of provisional application 63/079,767, filed on Sep. 17, 2020.
Prior Publication US 2022/0089708 A1, Mar. 24, 2022
Int. Cl. C07K 16/18 (2006.01); C12N 5/16 (2006.01); G01N 33/68 (2006.01)

CPC C07K 16/18 (2013.01) [C12N 5/163 (2013.01); G01N 33/6896 (2013.01); C07K 2317/14 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); G01N 2800/2835 (2013.01)]

4 Claims

1. A monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein:

i. the VH comprises heavy chain complementarity determining regions (HCDRs) 1-3 having the amino acid sequences of SEQ ID NOs:7-9, respectively; and

ii. the VL comprises light chain complementarity determining regions (LCDRs) 1-3 having the amino acid sequences of SEQ ID NOs:13-15, respectively.