US 12,351,621 B1
Composite collagen product and method of making thereof
Mohammad Z. Albanna, Chandler, AZ (US)
Assigned to Humabiologics, Inc., Phoenix, AZ (US)
Filed by Humabiologics, Inc., Phoenix, AZ (US)
Filed on Nov. 3, 2024, as Appl. No. 18/935,626.
Application 18/935,626 is a continuation in part of application No. 18/654,723, filed on May 3, 2024, granted, now 12,134,792.
Claims priority of provisional application 63/463,579, filed on May 3, 2023.
Int. Cl. C07K 14/78 (2006.01); A61L 27/24 (2006.01); A61L 27/26 (2006.01); A61L 27/36 (2006.01); A61L 27/58 (2006.01)
CPC C07K 14/78 (2013.01) 9 Claims
 
1. A manufactured composite collagen product comprising:
a) a soluble collagen component; and
b) an insoluble collagen component;
wherein the soluble collagen component is configured in the composite collagen product at a ratio to insoluble collagen component;
wherein the composite collagen is a sheet of collagen;
wherein the sheet of collagen is a membrane having has a thickness of 1 mm or less;
wherein the sheet of collagen comprises a plurality of sheets of collagen bonded together;
wherein the composite collagen has a first laver of composite collagen with a first ratio of soluble collagen component to insoluble collagen component and a second laver of composite collagen with a second ratio of soluble collagen component to insoluble collagen component, and wherein the first ratio of soluble collagen component to insoluble collagen component is between 0.25:1 and 1.75:1 and at least 25% greater than the second ratio of soluble collagen component to insoluble collagen component; and
wherein the first layer is configured on a first surface of the composite collagen product and wherein the second layer is configured on a second surface of the composite collagen product, wherein the second layer is opposite the first layer.