US 12,351,615 B2
Cell body targeted sensors
Or A. Shemesh, Cambridge, MA (US); Changyang Linghu, Cambridge, MA (US); Kiryl D. Piatkevich, Cambridge, MA (US); Edward S. Boyden, Cambridge, MA (US); and Won Min Park, Cambridge, MA (US)
Assigned to Massachuetts Institute of Technology, Cambridge, MA (US)
Appl. No. 17/312,445
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
PCT Filed Dec. 11, 2019, PCT No. PCT/US2019/065773
§ 371(c)(1), (2) Date Jun. 10, 2021,
PCT Pub. No. WO2020/123688, PCT Pub. Date Jun. 18, 2020.
Claims priority of provisional application 62/778,004, filed on Dec. 11, 2018.
Prior Publication US 2022/0048970 A1, Feb. 17, 2022
Int. Cl. C07K 14/705 (2006.01); A61B 5/00 (2006.01); C12N 13/00 (2006.01); G01N 33/50 (2006.01); A61B 1/04 (2006.01)
CPC C07K 14/705 (2013.01) [C12N 13/00 (2013.01); G01N 33/5091 (2013.01); A61B 1/043 (2013.01); A61B 5/0071 (2013.01); G01N 2500/10 (2013.01)] 8 Claims
 
1. A composition comprising a soma-targeting polypeptide fusion protein, wherein the soma-targeting polypeptide fusion protein comprises an EE-RR polypeptide or functional variant thereof; and an Anktail motif polypeptide or functional variant thereof, wherein the EE-RR polypeptide comprises the amino acid sequence of SEQ ID NO: 2; the functional variant of the EE-RR polypeptide has at least 90% sequence identity to SEQ ID NO: 2; the Anktail motif polypeptide comprises the amino acid sequence of SEQ ID NO: 1; and the functional variant of the Anktail motif polypeptide has at least 90% sequence identity to SEQ ID NO: 1.