	US 12,351,610 B2
	Interferon regulatory factor 5 inhibitors and uses thereof
Betsy J. Barnes, Glenwood Landing, NY (US); and Shan Sun, Wingdale, NY (US)
Assigned to THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, Manhasset, NY (US)
Appl. No. 17/608,487
Filed by THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, Manhasset, NY (US)
PCT Filed May 4, 2020, PCT No. PCT/US2020/031283 § 371(c)(1), (2) Date Nov. 3, 2021, PCT Pub. No. WO2020/227194, PCT Pub. Date Nov. 12, 2020.
Claims priority of provisional application 62/844,894, filed on May 8, 2019.
Prior Publication US 2022/0220168 A1, Jul. 14, 2022
Int. Cl. C07K 14/47 (2006.01); A61K 38/00 (2006.01); A61P 37/00 (2006.01)

CPC C07K 14/47 (2013.01) [A61P 37/00 (2018.01); A61K 38/00 (2013.01)]

11 Claims

1. A polypeptide consisting of a cell penetrating amino acid sequence and an interferon regulatory factor 5 (IRF5) targeting amino acid sequence, wherein the IRF5 targeting amino acid sequence consists of one or more of RHATRHG (SEQ ID NO:1), KSRDFRL (SEQ ID NO:2) and GPRDMPP (SEQ ID NO:3).