US 12,351,596 B2
Tetrasaccharides for the diagnosis, prevention, and treatment of melioidosis and glanders
Charles Gauthier, Laval (CA); and Maude Cloutier, Windsor (CA)
Assigned to INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Quebec (CA)
Appl. No. 17/595,998
Filed by INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Quebec (CA)
PCT Filed Apr. 17, 2020, PCT No. PCT/CA2020/050516
§ 371(c)(1), (2) Date Dec. 1, 2021,
PCT Pub. No. WO2020/243815, PCT Pub. Date Dec. 10, 2020.
Claims priority of provisional application 62/857,346, filed on Jun. 5, 2019.
Prior Publication US 2022/0227801 A1, Jul. 21, 2022
Int. Cl. C07H 15/08 (2006.01); A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 39/385 (2006.01); A61K 47/64 (2017.01); A61P 31/04 (2006.01); A61P 37/04 (2006.01); C07H 1/00 (2006.01)
CPC C07H 15/08 (2013.01) [A61K 39/0208 (2013.01); A61K 39/385 (2013.01); A61K 47/6415 (2017.08); A61K 47/646 (2017.08); A61P 31/04 (2018.01); A61P 37/04 (2018.01); C07H 1/00 (2013.01); A61K 2039/6087 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A conjugate with the formula:

OG Complex Work Unit Chemistry
wherein:
Ac represents an acetyl (CH3—C(═O)—) group,
Me represents a methyl group,
R1 represents —H or an acetyl group,
R2 represents —H or an acetyl group,
L represents a C2-C6 alkylene group, or -L- together with the oxygen atom to which it is attached forms 1 to 3 polyethylene glycol repeat units and
molecule is a vaccine carrier molecule.